Evidence map›Paper›PMID 30088035›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2018

STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca

Carlos Pascual-Caro, Maria Berrocal, Aida M Lopez-Guerrero, Alberto Alvarez-Barrientos, Eulalia Pozo-Guisado, Carlos Gutierrez-Merino, Ana M Mata, Francisco Javier Martin-Romero

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Article
  3. The CaCell reports. Medicine · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Store-operated calcium entry in the satellite glial cells of rat sympathetic ganglia.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024
    Article
  12. Neuronal Store-Operated Calcium Channels.Molecular neurobiology · 2023
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Carlos Pascual-CaroDepartment of Biochemistry and Molecular Biology, School of Life Sciences and Institute of Molecular Pathology Biomarkers, University of Extremadura, Avenida de Elvas s/n, 06006, Badajoz, Spain.
Maria BerrocalDepartment of Biochemistry and Molecular Biology, School of Life Sciences and Institute of Molecular Pathology Biomarkers, University of Extremadura, Avenida de Elvas s/n, 06006, Badajoz, Spain.
Aida M Lopez-GuerreroDepartment of Biochemistry and Molecular Biology, School of Life Sciences and Institute of Molecular Pathology Biomarkers, University of Extremadura, Avenida de Elvas s/n, 06006, Badajoz, Spain.
Alberto Alvarez-BarrientosApplied Bioscience Facility, University of Extremadura, Avenida de Elvas s/n, 06006, Badajoz, Spain.
Eulalia Pozo-GuisadoDepartment of Cell Biology, School of Medicine and Institute of Molecular Pathology Biomarkers, University of Extremadura, Avenida de Elvas s/n, 06006, Badajoz, Spain.
Carlos Gutierrez-MerinoDepartment of Biochemistry and Molecular Biology, School of Life Sciences and Institute of Molecular Pathology Biomarkers, University of Extremadura, Avenida de Elvas s/n, 06006, Badajoz, Spain.
Ana M MataDepartment of Biochemistry and Molecular Biology, School of Life Sciences and Institute of Molecular Pathology Biomarkers, University of Extremadura, Avenida de Elvas s/n, 06006, Badajoz, Spain.
Francisco Javier Martin-RomeroDepartment of Biochemistry and Molecular Biology, School of Life Sciences and Institute of Molecular Pathology Biomarkers, University of Extremadura, Avenida de Elvas s/n, 06006, Badajoz, Spain. fjmartin@unex.es.ORCID 0000-0001-6796-7396
Universidad de Extremadura · ES

Funding

Junta de Extremadura (ES) GRU15077Junta de Extremadura (ES) GRU15139Junta de Extremadura (ES) IB16088Ministerio de Economía y Competitividad BFU2014-53641-PMinisterio de Economía y Competitividad BFU2017-82716-PMinisterio de Economía y Competitividad BFU2017-85723-PMinisterio de Economía y Competitividad (ES) BFU2014-52401-P
6 · The paper itself

Abstract

STIM1 is an endoplasmic reticulum protein with a role in Ca KEY MESSAGES: STIM1 protein expression decreases with the progression of neurodegeneration in Alzheimer's disease. STIM1 is essential for cell viability in differentiated SH-SY5Y cells. STIM1 deficiency triggers voltage-regulated Ca

Indexed as

AgedAged, 80 and overAlzheimer DiseaseCalciumCalcium Channels, L-TypeCell DeathCell Line, TumorHumansNeoplasm ProteinsPrefrontal CortexStromal Interaction Molecule 1CalciumCalcium Channels, L-TypeNeoplasm ProteinsSTIM1 protein, humanStromal Interaction Molecule 1Alzheimer’s diseaseCalciumCRISPRSH-SY5YSTIM1VOCC

Identifiers

PMID30088035
PMCPMC6133163
OpenAlexW2886323987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.