ArticleExperimental brain research2018
Rapid olfactory discrimination learning in adult zebrafish.
Article in Experimental brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Representational learning by optimization of neural manifolds in an olfactory memory network.Nature neuroscience · 2026Article
- How to Make Your Fish Work for You: Tips from Ethology and Ecology for Finding Appropriate Unconditioned Stimuli for Learning Studies withAnimals : an open access journal from MDPI · 2026Article
- Exploring visual categorical learning in teleost fish Danio rerio and Xenotoca eiseni.Animal cognition · 2026Article
- Olfactory Impairment and Recovery in Zebrafish (Biology · 2025Article
- Assessment of Replicability and Efforts to Refine an Operant Conditioning Procedure for Larval Zebrafish.Animals : an open access journal from MDPI · 2024Article
- A simple semi-automated home-tank method and procedure to explore classical associative learning in adult zebrafish.Behavior research methods · 2024Article
- Learning and memory formation in zebrafish: Protein dynamics and molecular tools.Frontiers in cell and developmental biology · 2023Review
- Article
- A scalable assay for chemical preference of small freshwater fish.Frontiers in behavioral neuroscience · 2022Article
- Associative conditioning remaps odor representations and modifies inhibition in a higher olfactory brain area.Nature neuroscience · 2019Article
- The Olfactory System of Zebrafish as a Model for the Study of Neurotoxicity and Injury: Implications for Neuroplasticity and Disease.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The zebrafish is a model organism to study olfactory information processing, but efficient behavioral procedures to analyze olfactory discrimination and memory are lacking. We devised an automated odor discrimination task for adult zebrafish based on olfactory conditioning of feeding behavior. Presentation of a conditioned odor (CS+), but not a neutral odor (CS-) was followed by food delivery at a specific location. Fish developed differential behavioral responses to CS+ and CS- within a few trials. The behavioral response to the CS+ was complex and included components reminiscent of food search such as increased swimming speed and water surface sampling. Appetitive behavior was therefore quantified by a composite score that combined measurements of multiple behavioral parameters. Robust discrimination behavior was observed in different strains, even when odors were chemically similar, and learned preferences could overcome innate odor preferences. These results confirm that zebrafish can rapidly learn to make fine odor discriminations. The procedure is efficient and provides novel opportunities to dissect the neural mechanisms underlying olfactory discrimination and memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.