Evidence map›Paper›PMID 30087582›Full record

ReviewCancer cell international2018

Prognostic significance of galectin-1 expression in patients with cancer: a meta-analysis.

Rongzu Wu, Tingchun Wu, Kai Wang, Shicheng Luo, Zhen Chen, Min Fan, Dong Xue, Hao Lu, Qianfeng Zhuang, Xianlin Xu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer cell international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Galectins for Diagnosis and Prognostic Assessment of Human Diseases: An Overview of Meta-Analyses.Medical science monitor : international medical journal of experimental and clinical research · 2020
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  12. Functional and metabolic targeting of natural killer cells to solid tumors.Cellular oncology (Dordrecht, Netherlands) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rongzu Wu *Department of Urology, XiShan People's Hospital, 1128 Anzhen Street, Wuxi, 214011 Jiangsu China.
Tingchun Wu *2Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu China.
Kai Wang2Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu China.
Shicheng Luo2Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu China.
Zhen Chen2Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu China.
Min Fan2Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu China.
Dong Xue2Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu China.
Hao Lu2Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu China.
Qianfeng Zhuang2Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu China.
Xianlin Xu3Department of Urology, Sir Run Run Shaw Hospital, The Third Affiliated Hospital of Nanjing Medical University, Jiangning District, Nanjing, Jiangsu China.ORCID 0000-0001-8456-6463
Soochow University · CNSir Run Run Shaw Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognostic significance of galectin-1 (Gal-1) expression in cancerous patients has been assessed for several years while the results remain controversial. Thus, we performed the first comprehensive meta-analysis to evaluate the prognostic value of Gal-1 expression in cancerous patients.

methodsWe searched Pubmed, Embase and Web of Science to recruit studies on the prognostic impact of Gal-1 expression in cancerous patients. Eighteen studies containing 2674 patients were involved in this meta-analysis until March 30, 2018. Pooled hazard ratios (HRs) with 95% confidence interval (95% CI) were calculated to estimate the effect using random-effects model.

resultsThe pooled results revealed that high Gal-1 expression in cancer tissue associated with a poor OS (HR = 1.79, 95% CI 1.54-2.08, P < 0.001). In the subgroup of tumor type, it's observed that high Gal-1 expression was significant correlated with poor OS in digestive cancers without heterogeneity (HR = 1.94, 95% CI 1.64-2.30, P < 0.001; fixed-effects model; I

conclusionsOur present meta-analysis indicates that high Gal-1 expression might be a predictive factor of poor prognosis in cancers, particularly in digestive cancers.

Indexed as

CancerGalectin-1Meta-analysisPrognosis

Identifiers

PMID30087582
PMCPMC6076397
OpenAlexW2887445158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.