SynthesisMolecular psychiatry2020
Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population.Molecular psychiatry · 2024Pooled it
- Associations Between Avoidant/Restrictive Food Intake Disorder Dimensions and Obsessive-Compulsive Symptomatology.European eating disorders review : the journal of the Eating Disorders Association · 2026Article
- Cross-ancestry and cross-disorder transferability of polygenic risk scores for obsessive-compulsive disorder.Translational psychiatry · 2026Article
- Advancements in the Understanding of the Genetics of Obsessive-Compulsive Disorder (OCD).Current psychiatry reports · 2026Review
- Neural circuits regulating activity-based anorexia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Metabolomic ageing across mental and behavioural disorders.BMJ mental health · 2026Article
- Temporal Trends in the Epidemiology of Eating Disorders Between 2000 and 2022: A Danish Register Study of Their Incidence and Comorbidities.European eating disorders review : the journal of the Eating Disorders Association · 2026Article
- A unified theory of restrictive and addictive eating: a life course model integrating generational transmission, neurodevelopmental risk, and ultra-processed food use disorder-a theoretical review.Journal of eating disorders · 2026Review
- A scoping review of eating disorder symptoms and mental health during the postpartum period: predictors, course, and consequences for mothers and infants.Journal of eating disorders · 2026Review
- Eating Disorders and Parkinson's Disease - 2: Population Burden, Genetic Epidemiology and Shared Genomics.medRxiv : the preprint server for health sciences · 2026Article
- Rare coding variation in OCD implicates shared genes with other psychiatric disorders.medRxiv : the preprint server for health sciences · 2025Article
- Utilising genomic association data for causal inference in anorexia nervosa.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Toward a Genetic Signature of Resistance to Activity-Based Anorexia in Striatal Projecting Cortical Neurons.The International journal of eating disorders · 2025Article
- Genetic risk and transdiagnostic traits in anorexia nervosa, obsessive-compulsive disorder, and schizophrenia.Psychological medicine · 2025Article
- Examining the biological causes of eating disorders to inform treatment strategies.Nature reviews. Neuroscience · 2025Review
- Obsessive-compulsive symptoms in individuals with a history of eating disorders.Journal of affective disorders · 2025Observational
- Sociodemographic and clinical characteristics of 1,234 individuals diagnosed with trichotillomania in the Swedish National Patient Register.Scientific reports · 2025Article
- Convergent molecular signatures across eating disorders and obsessive-compulsive disorder in the human brain.medRxiv : the preprint server for health sciences · 2024Article
- Association between childhood maltreatment and obsessive-compulsive disorder comorbid with eating disorders: a cross-sectional study.Journal of eating disorders · 2024Article
- A transdiagnostic and translational framework for delineating the neuronal mechanisms of compulsive exercise in anorexia nervosa.The International journal of eating disorders · 2024Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Zeynep Yilmaz *Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-8145-1596
Matthew Halvorsen *Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Julien BryoisDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4747-2166
Dongmei YuDepartment of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Laura M ThorntonDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Stephanie ZerwasDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nadia MicaliDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Rainald MoessnerDepartment of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany.
Christie L BurtonGenetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-8955-6528
Gwyneth ZaiNeurogenetics Section, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Lauren ErdmanGenetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Martien J KasGroningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
Paul D ArnoldGenetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Lea K DavisVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5143-2282
James A KnowlesSUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Gerome BreenMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Jeremiah M ScharfDepartment of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Gerald NestadtDepartment of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, MD, USA.
Carol A Mathews *Department of Psychiatry, Genetics Institute, University of Florida, Gainesville, FL, USA.
Cynthia M Bulik *Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Manuel Mattheisen *Department of Biomedicine, Aarhus University, Aarhus, Denmark.
James J Crowley *Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. crowley@unc.edu.
Eating Disorders Working Group of the Psychiatric Genomics Consortium, Tourette Syndrome/Obsessive–Compulsive Disorder Working Group of the Psychiatric Genomics Consortium
Funding
OCD Collaborative Genetics Association StudyR01MH071507 · NIMH · JOHNS HOPKINS UNIVERSITY · PI NESTADT, GERALD · 2007 to 2010
$6.5M2/7 Psychiatric Genomics Consortium: Finding Actionable VariationU01MH109539 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DALY, MARK JOSEPH · 2016 to 2020
$4.7M1/7 PGC: Advancing Discovery and ImpactR01MH124871 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, SULLIVAN, PATRICK F · 2021 to 2025
$3.5MObsessive-compulsive disorder (OCD) Collaborative Genetics Association StudyR01MH079489 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI GELLER, DANIEL A · 2007 to 2010
$3.4MGenetic & Environmental Predictors of Tourette Syndrome & OCD in DenmarkR01MH105500 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CROWLEY, JAMES JOSEPH · 2015 to 2019
$3.0MOCD: Novel Comparative Genomic Approaches to Identify Disease and Treatment MechanismsR01MH110427 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CROWLEY, JAMES JOSEPH · 2016 to 2021
$3.0MPostdoctoral Research Training in Eating DisordersT32MH076694 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2007 to 2016
$1.8MOCD Collaborative Genetics Association StudyR01MH079488 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FYER, ABBY J · 2007 to 2010
$906kObsessive-compulsive disorder (OCD) Collaborative Genetics Association StudyR01MH079494 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KNOWLES, JAMES A · 2007 to 2011
$840kOCD Collaborative Genetics Association StudyR01MH079487 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2007 to 2010
$797kShared Genetic and Environmental Risk Factors for Anorexia Nervosa and Obsessive-Compulsive Disorder in DenmarkK01MH109782 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YILMAZ, ZEYNEP · 2016 to 2019
$620kNIMH NIH HHS K01 MH109782NIMH NIH HHS R01 MH071507NIMH NIH HHS R01 MH079487NIMH NIH HHS R01 MH079488NIMH NIH HHS R01 MH079489NIMH NIH HHS R01 MH079494NIMH NIH HHS R01 MH105500NIMH NIH HHS R01 MH110427NIMH NIH HHS R01 MH124871NIMH NIH HHS T32 MH076694NIMH NIH HHS U01 MH109539
Abstract
Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) are often comorbid and likely to share genetic risk factors. Hence, we examine their shared genetic background using a cross-disorder GWAS meta-analysis of 3495 AN cases, 2688 OCD cases, and 18,013 controls. We confirmed a high genetic correlation between AN and OCD (r
Indexed as
Anorexia NervosaObsessive-Compulsive DisorderBody Mass IndexComorbidityGenome-Wide Association StudyHumansPhenotype
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