ArticleHypertension research : official journal of the Japanese Society of Hypertension2018
Association between age at menarche and blood pressure in adulthood: is obesity an important mediator?
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 38 citations in OpenAlex.
- Associations of Reproductive Factors With Hypertension Prevalence and Blood Pressure Levels in Female Nurses: A Cross-Sectional Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- A cross-sectional study of environmental quality and the timing of menarche and menopause in India using national survey and environmental monitoring datasets.Communications medicine · 2026Article
- Age at Menarche and Risk of Hypertensive Disorders of Pregnancy: A Retrospective Cohort Study.Clinics and practice · 2026Article
- Age at menarche and blood pressure in late adolescence: the role of body adiposity in a Brazilian birth cohort.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2026Article
- Early Menarche and Hypertension Among Postmenopausal Women: The Mediating Role of Obesity.Epidemiologia (Basel, Switzerland) · 2025Article
- Association of Age at Menarche with General and Abdominal Obesity in Young Women.Medicina (Kaunas, Lithuania) · 2024Article
- Body Mass Index and Hypertension as Mediators of the Association Between Age at Menarche and Subclinical Atherosclerosis: A Sex-Specific Mendelian Randomization Analysis.Journal of the American Heart Association · 2024Article
- Adiposity indices and their higher predictive value for new-onset hypertension in metabolically healthy young women: findings from a population-based prospective cohort study.BMC cardiovascular disorders · 2024Article
- Reproductive risk factors across the female lifecourse and later metabolic health.Cell metabolism · 2024Review
- Association between homocysteine and blood pressure in the NHANES 2003-2006: the mediating role of Vitamin C.Frontiers in nutrition · 2024Article
- Early puberty: a review on its role as a risk factor for metabolic and mental disorders.Frontiers in pediatrics · 2024Review
- Association of age at menarche with gestational hypertension and preeclampsia: A large prospective cohort in China.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Mediation Effect of Obesity on the Association of Age at Menarche With Blood Pressure Among Women in Southwest China.Journal of the American Heart Association · 2023Article
- The association between early menarche and higher-risk cardiometabolic profile: a dose-response analysis of the Tabari cohort at enrollment phase.Frontiers in cardiovascular medicine · 2023Article
- Article
- Associations between Age at Menarche and Dietary Patterns with Blood Pressure in Southwestern Chinese Adults.Nutrients · 2022Article
- Effect of air pollution on age at menarche in polish females, born 1993-1998.Scientific reports · 2022Article
- Reproductive lifespan in association with risk of hypertension among Chinese postmenopausal women: Results from a large representative nationwide population.Frontiers in cardiovascular medicine · 2022Article
- Systolic blood pressure as the mediator of the effect of early menarche on the risk of coronary artery disease: A Mendelian randomization study.Frontiers in cardiovascular medicine · 2022Article
- Age at Menarche and Menopause, Reproductive Lifespan, and Risk of Cardiovascular Events Among Chinese Postmenopausal Women: Results From a Large National Representative Cohort Study.Frontiers in cardiovascular medicine · 2022Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the association between age at menarche, and adiposity and blood pressure in adulthood, as well as the mediation effects of adiposity on the relationship between age at menarche and blood pressure. This was a nationally representative survey conducted in Brazil in 2013 (Brazilian Health Survey). The participants included 33,715 women between 18 and 100 years old. Age at menarche was self-reported and outcomes (body mass index [BMI], waist circumference, and blood pressure) were objectively measured. As covariates, data on chronological age, race, educational status, tobacco smoking, leisure physical activity, TV viewing, sodium consumption, alcohol drinking, menopause status, and antihypertensive medication use were obtained by questionnaires. Negative and linear relationships were observed between age at menarche and adiposity indicators. Early maturers presented a greater prevalence of obesity (waist circumference: 56.3% [54.0-58.7] vs. 52.4% [51.4-53.5], BMI: 32.4% [30.2-34.6] vs. 25.1% [24.2-26.0]) than on time/late maturers. Age at menarche was significantly inversely related to blood pressure and adiposity in adulthood (p < 0.05), although these associations were weaker than the association between obesity and early menarche. Adiposity indicators mediated the relationship between age at menarche, and systolic (partly) and diastolic (fully) blood pressure. In conclusion, early maturation is related to obesity and higher blood pressure in adulthood. Obesity is an important mediator of the influence of early maturation on high blood pressure in women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.