ArticleScientific reports2018
Citrobacter freundii fitness during bloodstream infection.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed, 76 citations in OpenAlex.
- Article
- Plasmids of the multidrug-resistantMicrobiology spectrum · 2026Article
- Article
- Biological characteristics and genome analysis of Citrobacter freundii phage K1M.Archives of virology · 2025Article
- Bloodstream infections: mechanisms of pathogenesis and opportunities for intervention.Nature reviews. Microbiology · 2025Review
- Synergistic Effects of Probiotics and Lifestyle Interventions on Intestinal Microbiota Composition and Clinical Outcomes in Obese Adults.Metabolites · 2025Article
- Patterns of Klebsiella pneumoniae bacteremic dissemination from the lung.Nature communications · 2025Article
- Adenylate kinase gene polymerase chain reaction-restriction fragment length polymorphism to differentiate Escherichia coli, Escherichia fergusonii, and Citrobacter freundii: a molecular diagnostic study.Journal of Yeungnam medical science · 2025Article
- Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals.Nature microbiology · 2025Article
- Asymptomatic bacteriuria screening for developing countries using a modified water quality test kit.Applied and environmental microbiology · 2024Article
- Investigation of Carriers ofAnimals : an open access journal from MDPI · 2024Article
- Fitness factor genes conserved within the multi-species core genome of Gram-negative Enterobacterales species contribute to bacteremia pathogenesis.PLoS pathogens · 2024Article
- A sophisticated virulence repertoire and colistin resistance of Citrobacter freundii ST150 from a patient with sepsis admitted to ICU in a tertiary care hospital in Uganda, East Africa: Insight from genomic and molecular docking analyses.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024Article
- Determinants of bacterial survival and proliferation in blood.FEMS microbiology reviews · 2024Review
- In-patient evolution of a high-persisterProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Citrobacter koseri related abortion and fetal septicemia in cattle.The Journal of veterinary medical science · 2023Article
- Comparative Genomic Analyses of Virulence and Antimicrobial Resistance inMicroorganisms · 2023Article
- Klebsiella pneumoniae causes bacteremia using factors that mediate tissue-specific fitness and resistance to oxidative stress.PLoS pathogens · 2023Article
- Propolis Silver Nanoparticles as an Adjuvant in Immunization of Rats withArchives of Razi Institute · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sepsis resulting from microbial colonization of the bloodstream is a serious health concern associated with high mortality rates. The objective of this study was to define the physiologic requirements of Citrobacter freundii in the bloodstream as a model for bacteremia caused by opportunistic Gram-negative pathogens. A genetic screen in a murine host identified 177 genes that contributed significantly to fitness, the majority of which were broadly classified as having metabolic or cellular maintenance functions. Among the pathways examined, the Tat protein secretion system conferred the single largest fitness contribution during competition infections and a putative Tat-secreted protein, SufI, was also identified as a fitness factor. Additional work was focused on identifying relevant metabolic pathways for bacteria in the bloodstream environment. Mutations that eliminated the use of glucose or mannitol as carbon sources in vitro resulted in loss of fitness in the murine model and similar results were obtained upon disruption of the cysteine biosynthetic pathway. Finally, the conservation of identified fitness factors was compared within a cohort of Citrobacter bloodstream isolates and between Citrobacter and Serratia marcescens, the results of which suggest the presence of conserved strategies for bacterial survival and replication in the bloodstream environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.