ArticleNature communications2018
Developmental seizures and mortality result from reducing GABA
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Axo-axonic cells in neuropsychiatric disorders: a systematic review.Frontiers in cellular neuroscience · 2023Pooled it
- Addressing the Limits of Emx2 Therapy of Glioblastoma Multiforme by Transgene Insulation and Epigenetic Pharmacological Intervention.Biomedicines · 2026Article
- GABASynapse (New York, N.Y.) · 2026Review
- The role of GABANeuroscience and biobehavioral reviews · 2026Review
- Coordinated Pre- and Postsynaptic Protein Dynamics Underlie Rapid Sema4D-Induced Inhibitory Synapse Assembly.eNeuro · 2026Article
- Autophagic Pathway on GABARAP Involved in GABANeurochemical research · 2026Review
- Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- Autism-associated ARHGEF9 variants impair GABAergic synapses and ultrasonic communication by reducing gephyrin phosphorylation.Molecular psychiatry · 2026Article
- Coordinated pre- and postsynaptic protein dynamics underlie rapid Sema4D-mediated inhibitory synapse assembly.bioRxiv : the preprint server for biology · 2026Article
- Carvone derived cannabidiol enantiomers as novel anticonvulsants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Hide-and-Seek genome editing reveals that Gephyrin is required for axo-axonic synapse assembly.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Milestone Review: Unlocking the Proteomics of Glycine Receptor Complexes.Journal of neurochemistry · 2025Review
- Developmental and Epileptic Encephalopathy: Pathogenesis of Intellectual Disability Beyond Channelopathies.Biomolecules · 2025Review
- A novel de novo GABRA2 gene missense variant causing developmental epileptic encephalopathy in a Chinese patient.Annals of clinical and translational neurology · 2025Article
- Impaired axon initial segment structure and function in a model ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- GABA system as the cause and effect in early development.Neuroscience and biobehavioral reviews · 2024Review
- Motor learning changes the axon initial segment of the spinal motoneuron.The Journal of physiology · 2024Article
- The gephyrin scaffold modulates cortical layer 2/3 pyramidal neuron responsiveness to single whisker stimulation.Scientific reports · 2024Article
- Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors.Journal of translational medicine · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 5 countries.
Rochelle M HinesDepartment of Neuroscience, Tufts University School of Medicine, Boston, 02111, MA, USA. Rochelle.Hines@unlv.edu.ORCID http://orcid.org/0000-0002-0459-7911
Hans Michael MaricRudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Würzburg, D-97080, Germany.ORCID http://orcid.org/0000-0002-2719-4752
Dustin J HinesDepartment of Neuroscience, Tufts University School of Medicine, Boston, 02111, MA, USA.
Amit ModgilDepartment of Neuroscience, Tufts University School of Medicine, Boston, 02111, MA, USA.
Patrizia PanzanelliDepartment of Neuroscience Rita Levi Montalcini, University of Turin, Turin, 10126, Italy.
Yasuko NakamuraDepartment of Neuroscience, Tufts University School of Medicine, Boston, 02111, MA, USA.
Anna J NathansonDepartment of Neuroscience, Tufts University School of Medicine, Boston, 02111, MA, USA.
Alan CrossAstraZeneca Neuroscience iMED, Biotech Unit, Boston, 02451, MA, USA.
Tarek DeebDepartment of Neuroscience, Tufts University School of Medicine, Boston, 02111, MA, USA.
Nicholas J BrandonAstraZeneca Neuroscience iMED, Biotech Unit, Boston, 02451, MA, USA.
Paul DaviesDepartment of Neuroscience, Tufts University School of Medicine, Boston, 02111, MA, USA.
Jean-Marc FritschyInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, 8057, Switzerland.ORCID http://orcid.org/0000-0002-8552-3702
Hermann SchindelinRudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Würzburg, D-97080, Germany.ORCID http://orcid.org/0000-0002-2067-3187
Stephen J MossDepartment of Neuroscience, Tufts University School of Medicine, Boston, 02111, MA, USA. Stephen.Moss@tufts.edu.
Tufts University · USUniversity of Würzburg · DEAstraZeneca (United States) · USUniversity of Turin · ITUniversity of Zurich · CH
Funding
The Synthesis of GABA in Epileptic BrainP01NS054900 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI COULTER, DOUGLAS A · 2007 to 2011
$6.4MModulation of KCC2 activity and the postnatal development of synaptic inhibitionR01NS101888 · NINDS · TUFTS UNIVERSITY BOSTON · PI DEEB, TAREK ZIAD, MOSS, STEPHEN J · 2017 to 2021
$2.3MDissecting Mechanisms of GABAB-GIRK Plasticity with PsychostimulantsR01DA037170 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MOSS, STEPHEN J, SLESINGER, PAUL A · 2014 to 2018
$2.1MNovel actions of neurosteroids on GABA (A) receptor traffickingR01MH097446 · NIMH · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2013 to 2017
$2.1MNovel actions of neurosteroids on GABA (A) receptor traffickingR01NS108378 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2018 to 2022
$2.0MDeficits in KCC2 activity and the pathophysiology of Status EpilepticusR01NS087662 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2014 to 2018
$2.0MDeficits in KCC2 activity and the pathophysiology of Autism spectrum disordersR21MH106954 · NIMH · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2015 to 2016
$454kThe role of dynamin-1 in the trafficking of GABA(B) receptorsR03NS065725 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2009 to 2011
$107kNIDA NIH HHS R01 DA037170NIMH NIH HHS R01 MH097446NIMH NIH HHS R21 MH106954NINDS NIH HHS P01 NS054900NINDS NIH HHS R01 NS087662NINDS NIH HHS R01 NS101888NINDS NIH HHS R01 NS108378NINDS NIH HHS R03 NS065725
Abstract
Fast inhibitory synaptic transmission is mediated by γ-aminobutyric acid type A receptors (GABA
Indexed as
AnimalsBrainElectroencephalographyHEK293 CellsHeterocyclic Compounds, 2-RingHumansMiceMice, Inbred C57BLMutationPeptidesPhenotypeProtein BindingProtein DomainsReceptors, GABA-ARho Guanine Nucleotide Exchange FactorsSeizures4-amino-8-(2-fluoro-6-methoxy-phenyl)-N-propylcinnoline-3-carboxamideArhgef9 protein, mouseGabra2 protein, mouseHeterocyclic Compounds, 2-RingPeptidesReceptors, GABA-ARho Guanine Nucleotide Exchange Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.