SynthesisNutrients2018
Osteoarthritis and the Mediterranean Diet: A Systematic Review.
Synthesis in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 5 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- The effectiveness of dietary intervention in osteoarthritis management: a systematic review and meta-analysis of randomized clinical trials.European journal of clinical nutrition · 2025Pooled it
- Scientific evidence supporting the newly developed one-health labeling tool "Med-Index": an umbrella systematic review on health benefits of mediterranean diet principles and adherence in a planeterranean perspective.Journal of translational medicine · 2023Pooled it
- Evidence-Based Dietary Practices to Improve Osteoarthritis Symptoms: An Umbrella Review.Nutrients · 2023Pooled it
- The effects of dietary patterns and food groups on symptomatic osteoarthritis: A systematic review.Nutrition & dietetics : the journal of the Dietitians Association of Australia · 2023Pooled it
- Dietary Interventions with or without Omega-3 Supplementation for the Management of Rheumatoid Arthritis: A Systematic Review.Nutrients · 2021Pooled it
- An anti-inflammatory diet intervention for knee osteoarthritis: a feasibility study.BMC musculoskeletal disorders · 2022Trial
- Acid-responsive metal organic frameworks with photothermal effects for osteoarthritis multiple therapy.RSC advances · 2026Article
- Integrating TWAS, chemical-genomic networks, and experimental models: melatonin as a ferroptosis inhibitor in osteoarthritis therapy.Clinical rheumatology · 2026Article
- Nutritional Interventions in Osteoarthritis: Mechanisms, Clinical Evidence, and Translational Opportunities.Nutrients · 2026Review
- Effectiveness of Adapted Physical Activity on Quality of Life of Patients with Knee and Hip Replacement: A Randomized Pilot Study.Healthcare (Basel, Switzerland) · 2025Article
- Knee osteoarthritis rehabilitation: an integrated framework of exercise, nutrition, biomechanics, and physical therapist guidance-a narrative review.European journal of medical research · 2025Review
- Diet in Knee Osteoarthritis-Myths and Facts.Nutrients · 2025Review
- Relationship between cardiovascular health and osteoarthritis in middle-aged and elderly U.S. population: a cross-sectional NHANES study.BMC musculoskeletal disorders · 2025Article
- Links between short-chain fatty acids and osteoarthritis from pathology to clinic via gut-joint axis.Stem cell research & therapy · 2025Review
- Association of cardiovascular health with morbidity and mortality among U.S. adults with osteoarthritis: a population-based study.BMC public health · 2025Article
- Dietary acid load and the odds of knee osteoarthritis: a case-control study.Scientific reports · 2025Article
- Review
- Rethinking Osteoarthritis Management: Synergistic Effects of Chronoexercise, Circadian Rhythm, and Chondroprotective Agents.Biomedicines · 2025Article
- Ferroptosis in Osteoarthritis: Towards Novel Therapeutic Strategy.Cell proliferation · 2025Review
- The association between dietary fiber intake and osteoarthritis: a cross-sectional study from the 1999-2018 U.S. National Health and Nutrition Examination Survey.Journal of orthopaedic surgery and research · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) affects 240 million people globally. Few studies have examined the links between osteoarthritis and the Mediterranean diet (MD). The aim of this paper was to systematically review and analyze the epidemiological evidence in humans on the MD and its association with OA. A systematic search of EMBASE identified three studies that explored the association between MD and OA. Two of them were cross-sectional and the third one was a 16-week randomized clinical trial. Prisma declaration was followed to carry out this review. These studies described a positive association between a higher adherence to a MD and the quality of life of participants suffering OA. The prevalence of OA was lower in participants with a higher adherence to a Mediterranean diet. Biomarkers of inflammation and cartilage degradation related to OA were also analyzed and significant differences were detected only for IL1-α, which decreased in the MD group. Exploring the relationship between MD and OA is complex, moreover, the limited evidence and methodological differences in such studies makes it difficult to compare results. In conclusion, the three studies included in this systematic review demonstrated some relation between osteoarthritis and a Mediterranean diet. However, prospective and longer interventions are required to evaluate the long-term efficacy of the Mediterranean diet to improve symptomatology and preventing osteoarthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.