Evidence map›Paper›PMID 30087268›Full record

ArticleToxins2018

Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of

Yining Tan, Xiaoling Chen, Chengbang Ma, Xinping Xi, Lei Wang, Mei Zhou, James F Burrows, Hang Fai Kwok, Tianbao Chen

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yining TanNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK. ytan07@qub.ac.uk.
Xiaoling ChenNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK. xchen19@qub.ac.uk.
Chengbang MaNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK. c.ma@qub.ac.uk.
Xinping XiNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK. x.xi@qub.ac.uk.
Lei WangNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK. l.wang@qub.ac.uk.
Mei ZhouNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK. m.zhou@qub.ac.uk.ORCID 0000-0003-2576-0252
James F BurrowsNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK. j.burrows@qub.ac.uk.
Hang Fai KwokFaculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau, China. hfkwok@umac.mo.ORCID 0000-0002-6349-4517
Tianbao ChenNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK. t.chen@qub.ac.uk.ORCID 0000-0001-8011-9260
Queen's University Belfast · GBUniversity of Macau · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The skin secretions of the subfamily Phyllomedusinae have long been known to contain a number of compounds with antimicrobial potential. Herein, a biosynthetic dermaseptin-precursor cDNA was obtained from a

Indexed as

Amino Acid SequenceAmphibian ProteinsAnimalsAnti-Infective AgentsAntimicrobial Cationic PeptidesAntineoplastic AgentsAnuraCandida albicansCell Line, TumorCell SurvivalErythrocytesEscherichia coliHemolysisHumansHydrophobic and Hydrophilic InteractionsSkinAmphibian ProteinsAnti-Infective AgentsAntimicrobial Cationic PeptidesAntineoplastic Agentsdermaseptinanticancer activityantimicrobial activityantimicrobial peptide (AMP)anuran skin secretiondermaseptindrug design

Identifiers

PMID30087268
PMCPMC6115755
OpenAlexW2886493807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.