Evidence map›Paper›PMID 30087223›Full record

ArticleMarine drugs2018

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity.

Xiangyan Chen, Xia Zhao, Yanyun Gao, Jiaqi Yin, Mingyue Bai, Fahe Wang

Abstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Anticancer Activity of Green Synthesized ZnO Nanoparticles fromNanomaterials (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Brucine Entrapped Titanium Oxide Nanoparticle for Anticancer Treatment: AnAdvances in pharmacological and pharmaceutical sciences · 2024
    Article
  11. Review
  12. Selenium Bio-Nanocomposite Based onBioengineering (Basel, Switzerland) · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Characterization ofMarine drugs · 2022
    Article
  17. Review
  18. Review
  19. Article
  20. Green Metallic Nanoparticles: Biosynthesis to Applications.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiangyan ChenShandong Provincial Key laboratory of Glycoscience and Glycoengineering, and Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. cxyqin@126.com.ORCID 0000-0002-4060-1332
Xia ZhaoShandong Provincial Key laboratory of Glycoscience and Glycoengineering, and Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. zhaoxia@ouc.edu.cn.ORCID 0000-0002-4060-1332
Yanyun GaoShandong Provincial Key laboratory of Glycoscience and Glycoengineering, and Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. gaoyanyun1991@126.com.
Jiaqi YinShandong Provincial Key laboratory of Glycoscience and Glycoengineering, and Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. 18669859101@163.com.
Mingyue BaiShandong Provincial Key laboratory of Glycoscience and Glycoengineering, and Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. baimyue@126.com.
Fahe WangState Key Laboratory of Bioactive Seaweed Substances, Qingdao Brightmoon Seaweed Group Co., Ltd., Qingdao 266400, China. 86612019@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gold nanoparticles (AuNPs) have been widely used in catalysis, photothermal therapy, and targeted drug delivery. Carrageenan oligosaccharide (CAO) derived from marine red algae was used as a reducing and capping agent to obtain AuNPs by an eco-friendly, efficient, and simple synthetic route for the first time. The synthetic conditions of AuNPs were optimized by response surface methodology (RSM), and the CAO-AuNPs obtained were demonstrated to be ellipsoidal, stable and crystalline by means of transmission electron microscopy (TEM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The CAO-AuNPs showed localized surface plasmon resonance (LSPR) oscillation at about 530 nm with a mean diameter of 35 ± 8 nm. The zeta potential of CAO-AuNPs was around -20 mV, which was related to the negatively charged CAO around AuNPs. The CAO-AuNPs exhibited significant cytotoxic activities to HCT-116 and MDA-MB-231 cells, which could be a promising nanomaterial for drug delivery.

Indexed as

Antineoplastic AgentsAquatic OrganismsCarrageenanCatalysisDrug Delivery SystemsDrug Screening Assays, AntitumorGoldGreen Chemistry TechnologyHCT116 CellsHumansMetal NanoparticlesMicroscopy, Electron, TransmissionOligosaccharidesRhodophytaSurface Plasmon ResonanceX-Ray DiffractionAntineoplastic AgentsCarrageenanGoldOligosaccharidesanti-tumor activitycarrageenan oligosaccharidegold nanoparticlesgreen synthesisresponse surface methodology

Identifiers

PMID30087223
PMCPMC6117638

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.