ArticleProceedings of the National Academy of Sciences of the United States of America2018
Differential inhibition of pyramidal cells and inhibitory interneurons along the rostrocaudal axis of anterior piriform cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal.Nature communications · 2025Article
- Anterior Olfactory Cortices Differentially Transform Bottom-Up Odor Signals to Produce Inverse Top-Down Outputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Odors in space.Frontiers in neural circuits · 2024Review
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal reward contingency signals during rule-reversal.bioRxiv : the preprint server for biology · 2023Article
- Article
- Parvalbumin-Positive Interneurons Regulate Cortical Sensory Plasticity in Adulthood and Development Through Shared Mechanisms.Frontiers in neural circuits · 2022Review
- Target-specific control of piriform cortical output via distinct inhibitory circuits.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Article
- Spatially extended balanced networks without translationally invariant connectivity.Journal of mathematical neuroscience · 2020Article
- Article
- Cortical processing of configurally perceived odor mixtures.Brain research · 2020Article
- Behavioral and Neurobiological Convergence of Odor, Mood and Emotion: A Review.Frontiers in behavioral neuroscience · 2020Article
- Glutamatergic Neurons in the Piriform Cortex Influence the Activity of D1- and D2-Type Receptor-Expressing Olfactory Tubercle Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Rapid Changes in Synaptic Strength After Mild Traumatic Brain Injury.Frontiers in cellular neuroscience · 2019Article
- Article
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Authors and funding
6 authors.
Funding
Abstract
The spatial representation of stimuli in sensory neocortices provides a scaffold for elucidating circuit mechanisms underlying sensory processing. However, the anterior piriform cortex (APC) lacks topology for odor identity as well as afferent and intracortical excitation. Consequently, olfactory processing is considered homogenous along the APC rostral-caudal (RC) axis. We recorded excitatory and inhibitory neurons in APC while optogenetically activating GABAergic interneurons along the RC axis. In contrast to excitation, we find opposing, spatially asymmetric inhibition onto pyramidal cells (PCs) and interneurons. PCs are strongly inhibited by caudal stimulation sites, whereas interneurons are strongly inhibited by rostral sites. At least two mechanisms underlie spatial asymmetries. Enhanced caudal inhibition of PCs is due to increased synaptic strength, whereas rostrally biased inhibition of interneurons is mediated by increased somatostatin-interneuron density. Altogether, we show differences in rostral and caudal inhibitory circuits in APC that may underlie spatial variation in odor processing along the RC axis.
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