Evidence map›Paper›PMID 30087172›Full record

ArticlemBio2018

Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae.

Crista B Wadsworth, Brian J Arnold, Mohamad R Abdul Sater, Yonatan H Grad

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 1 synthesis or guideline pooled it, 191 citations in OpenAlex.

  1. Pooled it
  2. Heterogeneity of azithromycin resistance markers inNew microbes and new infections · 2026
    Review
  3. Analysis of minimum inhibitory concentrations of azithromycin, ceftriaxone and ciprofloxacin forEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Diversity and evolution of a phase-variable multi-locus antigen inbioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. A novel commensalJournal of clinical microbiology · 2025
    Article
  16. Article
  17. CommensalAnnual review of microbiology · 2025
    Review
  18. Article
  19. Article
  20. Article

65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Crista B WadsworthDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA cwadsworth@hsph.harvard.edu ygrad@hsph.harvard.edu.ORCID 0000-0002-9449-2418
Brian J ArnoldDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0003-2113-940X
Mohamad R Abdul SaterDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0003-1912-0590
Yonatan H GradDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA cwadsworth@hsph.harvard.edu ygrad@hsph.harvard.edu.ORCID 0000-0001-5646-1314
Harvard University · USBrigham and Women's Hospital · US

Funding

Genomics approaches to elucidating pathways to antibiotic resistance in Neisseria gonorrhoeaeR01AI132606 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Yonatan H Grad · 2017 to 2026
$3.8M
NIAID NIH HHS R01 AI132606
6 · The paper itself

Abstract

Mosaic interspecifically acquired alleles of the multiple transferable resistance (

Indexed as

Anti-Bacterial AgentsAzithromycinBacterial ProteinsDrug Resistance, BacterialEpistasis, GeneticGene Expression Regulation, BacterialGonorrheaLinkage DisequilibriumMembrane ProteinsMembrane Transport ProteinsMutationNeisseria gonorrhoeaePromoter Regions, GeneticRepressor ProteinsTransformation, BacterialAnti-Bacterial AgentsAzithromycinBacterial ProteinsMembrane ProteinsMembrane Transport ProteinsMtrD protein, Neisseria gonorrhoeaemtrR protein, Neisseria gonorrhoeaeRepressor Proteinsantibiotic resistanceefflux pumpepistasisgonorrheamacrolideNeisseria gonorrhoeae

Identifiers

PMID30087172
PMCPMC6083905
OpenAlexW2950675215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.