Evidence map›Paper›PMID 30087068›Full record

ArticleAcademic radiology2019

A Model for Predicting Future FEV1 Decline in Smokers Using Hyperpolarized

Ryan J Baron, Hooman Hamedani, Stephen J Kadlecek, Ian F Duncan, Yi Xin, Sarmad Siddiqui, Mehrdad Pourfathi, Maurizio Cereda, Rahim R Rizi

Abstract read
In one paragraph

Article in Academic radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ryan J BaronDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Hooman HamedaniDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Stephen J KadlecekDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Ian F DuncanDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Yi XinDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Sarmad SiddiquiDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Mehrdad PourfathiDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Maurizio CeredaDepartment of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104.
Rahim R RiziDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104. Electronic address: rahim.rizi@uphs.upenn.edu.
University of Pennsylvania · US

Funding

Imaging-based characterization of the COPDGene cohortR01HL127969 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RIZI, RAHIM R · 2015 to 2018
$2.8M
NHLBI NIH HHS R01 HL127969
6 · The paper itself

Abstract

RATIONALE AND

objectivesThe purpose of this study was to assess the effectiveness of hyperpolarized helium-3 magnetic resonance (MR)-based imaging markers in predicting future forced expiratory volume in one second decline/chronic obstructive pulmonary disorder progression in smokers compared to current diagnostic techniques. MATERIALS AND

methodsTotal 60 subjects (15 nonsmokers and 45 smokers) participated in both baseline and follow-up visits (∼1.4 years apart). At both visits, subjects completed pulmonary function testing, a six-minute walk test , and the St. George Respiratory Questionnaire. Using helium-3 MR imaging, means (M) and standard deviations (H) of oxygen tension (P

resultsThe nonimaging prediction model included the St. George Respiratory Questionnaire total score, diffusing capacity of carbon monoxide by the alveolar volume (DLCO/VA), and distance walked in a six-minute walk test. A receiving operating character curve for this model yielded a sensitivity of 75% and specificity of 68% with an overall area under the curve of 65%. The imaging prediction model generated following the same methodology included ADC

conclusionThe imaging predication model generated from measurements obtained during

Indexed as

Models, BiologicalAdultArea Under CurveCase-Control StudiesDisease ProgressionForced Expiratory VolumeHeliumHumansIsotopesLungMagnetic Resonance ImagingMiddle AgedOxygenPartial PressurePulmonary Diffusing CapacityPulmonary Disease, Chronic ObstructiveHeliumHelium-3IsotopesOxygenCOPDFEV1 DeclineHelium-3 MRINoble gas MRI

Identifiers

PMID30087068
PMCPMC6361719
OpenAlexW2887964275

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.