ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2019
A comparison of treatment and outcomes of perihilar cholangiocarcinoma between Eastern and Western centers.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Pooled it
- Operative and Oncological Outcomes of Vascular Resection and Reconstruction for Perihilar Cholangiocarcinoma.Annals of surgical oncology · 2025Article
- Article
- Western and Eastern experience in treating perihilar cholangiocarcinoma: retrospective bi-centre study.BJS open · 2025Article
- Resectability and survival outcome in real world practice of 720 cholangiocarcinoma patients: intrahepatic, perihilar and distal cholangiocarcinoma.World journal of surgical oncology · 2024Article
- Parenchyma-Preserving Hepatectomy in Perihilar Cholangiocarcinoma: A Chance for Critical Patients?Visceral medicine · 2024Article
- Comment on "The Goal of Intraoperative Blood Loss in Major Hepatectomy Resection for Perihilar Cholangiocarcinoma Saving Patients From a Heavy Complication Burden".Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- A novel use of the comprehensive complication index in perihilar cholangiocarcinoma surgery.Hepatobiliary surgery and nutrition · 2024Article
- Article
- Article
- Essential updates 2021/2022: Update in surgical strategy for perihilar cholangiocarcinoma.Annals of gastroenterological surgery · 2023Review
- The failure to rescue factor: aftermath analyses on 224 cases of perihilar cholangiocarcinoma.Updates in surgery · 2023Article
- Fibrin-based haemostatic agents for reducing blood loss in adult liver resection.The Cochrane database of systematic reviews · 2023Review
- Editorial on "Hepatobiliary surgery and nutrition · 2022Article
- Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma.Hepatobiliary surgery and nutrition · 2022Article
- Concomitant Hepatic Artery Resection for Advanced Perihilar Cholangiocarcinoma: A Narrative Review.Cancers · 2022Review
- Preoperative Osteopenia Is Associated with Significantly Shorter Survival in Patients with Perihilar Cholangiocarcinoma.Cancers · 2022Article
- A novel nomogram for adult primary perihilar cholangiocarcinoma and considerations concerning lymph node dissection.Frontiers in surgery · 2022Article
- Vascular Resection in Perihilar Cholangiocarcinoma.Cancers · 2021Review
- Transhepatic Direct Approach to the "Limit of the Division of the Hepatic Ducts" Leads to a High R0 Resection Rate in Perihilar Cholangiocarcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundPerihilar cholangiocarcinoma (PHC) often requires extensive surgery which is associated with substantial morbidity and mortality. This study aimed to compare an Eastern and Western PHC cohort in terms of patient characteristics, treatment strategies and outcomes including a propensity score matched analysis.
methodsAll consecutive patients who underwent combined biliary and liver resection for PHC between 2005 and 2016 at two Western and one Eastern center were included. The overall perioperative and long-term outcomes of the cohorts were compared and a propensity score matched analysis was performed to compare perioperative outcomes.
resultsA total of 210 Western patients were compared to 164 Eastern patients. Western patients had inferior survival compared to the East (hazard-ratio 1.72 (1-23-2.40) P < 0.001) corrected for age, ASA score, tumor stage and margin status. After propensity score matching, liver failure rate, morbidity, and mortality were similar. There was more biliary leakage (38% versus 13%, p = 0.015) in the West.
conclusionThere were major differences in patient characteristics, treatment strategies, perioperative outcomes and survival between Eastern and Western PHC cohorts. Future studies should focus whether these findings are due to the differences in the treatment or the disease itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.