Evidence map›Paper›PMID 30086987›Full record

ArticleTrends in neurosciences2018

A Presynaptic Liquid Phase Unlocks the Vesicle Cluster.

Shan Shan H Wang, Pascal S Kaeser

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in neurosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Imaging the endocannabinoid signaling system.Journal of neuroscience methods · 2022
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Shan Shan H WangDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Pascal S KaeserDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: kaeser@hms.harvard.edu.

Funding

Dissecting the assembly of vertebrate neurotransmitter release sites-Research Supplements to Promote Diversity in Health-Related ResearchR01MH113349 · NIMH · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2017 to 2026
$6.1M
Molecular Dissection of Active Zone Functions in Neurotransmitter ReleaseR01NS083898 · NINDS · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2014 to 2026
$5.9M
Architecture and Function of Striatal Dopamine Signaling MachineryR01NS103484 · NINDS · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2017 to 2026
$4.7M
NIMH NIH HHS R01 MH113349NINDS NIH HHS R01 NS083898NINDS NIH HHS R01 NS103484
6 · The paper itself

Abstract

How are synaptic vesicles tied together in a nerve terminal? A recent study by Milovanovic and colleagues offers a new mechanism for this old and important problem: synapsin proteins establish a liquid phase that clusters vesicles. Liquid-liquid phase separation provides a fluid-like state that accommodates the dynamic demands of presynaptic vesicle traffic.

Indexed as

Presynaptic TerminalsSynapsinsLipidsSynaptic VesiclesLipidsSynapsinsactive zonephase separationsynapsesynapsinsynaptic vesiclevesicle tethering

Identifiers

PMID30086987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.