Evidence map›Paper›PMID 30086946›Full record

ArticleTalanta2018

In-capillary microextraction for direct mass spectrometry analysis of biological samples.

Yue Ren, Wenpeng Zhang, Ziqing Lin, Lane R Bushman, Peter L Anderson, Zheng Ouyang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Talanta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yue RenState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China; Weldon School of Biomedical Engineering and Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Wenpeng ZhangState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China; Weldon School of Biomedical Engineering and Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. Electronic address: zhan2360@purdue.edu.
Ziqing LinWeldon School of Biomedical Engineering and Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Lane R BushmanSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA.
Peter L AndersonSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA.
Zheng OuyangState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China; Weldon School of Biomedical Engineering and Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. Electronic address: ouyang@tsinghua.edu.cn.

Funding

Novel approaches for quantitative assessment of adherenceR01AI122298 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ANDERSON, PETER L. · 2016 to 2020
$3.4M
Quantification of Circulating Antigens for Pediatric TB Diagnosis andTreatment MonitoringR01AI122932 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI HU, TONY Y. · 2016 to 2019
$1.8M
Development of a Miniature Mass Spectromtry System for Point-of-Care ApplicationsR44GM119584 · NIGMS · PURSPEC TECHNOLOGIES, INC. · PI REN, YUE · 2017 to 2018
$1.3M
NIAID NIH HHS R01 AI122298NIAID NIH HHS R01 AI122932NIGMS NIH HHS R44 GM119584
6 · The paper itself

Abstract

Slug flow microextraction (SFME)-nanoESI was originally explored as a single-step sampling ionization method for MS analysis of biofluids. In this work, a comprehensive study and development of the SFME has been carried out. Revers-phase SFME was developed to analyze chemical compounds in oil samples. A three-phase SFME system was introduced as a suitable approach for analyzing polar compounds in biofluids. The impacts by the capillary inner diameter, solvent and sample properties were also investigated, leading the use of fused silica capillaries for performing SFME.

Indexed as

Body FluidsHydrophobic and Hydrophilic InteractionsLiquid Phase MicroextractionNanotechnologyOilsSolventsSpectrometry, Mass, Electrospray IonizationOilsSolventsBiofluidMass spectrometryPolar compoundsSlug flow microreaction

Identifiers

PMID30086946
PMCPMC6090165

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.