ArticleTumori2018
Denosumab in patients with aneurysmal bone cysts: A case series with preliminary results.
Article in Tumori, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Primary denosumab therapy for a three-column pediatric cervical aneurysmal bone cyst: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- The best solution is the simplest: advances in surgical and minimally invasive management of aneurysmal and simple bone cysts.Journal of orthopaedic surgery and research · 2026Review
- ANEURYSMAL BONE CYST: A CASE SERIES OF AN AGGRESSIVE BENIGN TUMOR.Acta ortopedica brasileira · 2026Article
- Significant Response to Denosumab Yet with Severe Rebound Hypercalcemia in a 9-Year-Old Boy with Aneurysmal Bone Cyst: A Case Report.Children (Basel, Switzerland) · 2025Article
- Rethinking the role of bisphosphonates after denosumab treatment in locally advanced or unresectable aneurysmal bone cysts: A meta-analysis.World journal of orthopedics · 2025Article
- A Short Course of Preoperative Denosumab Injection Followed by Surgery in High-Risk Giant Cell Tumors of the Extremities: A Retrospective Study.Indian journal of surgical oncology · 2024Article
- Aneurysmal Bone Cyst of the Distal Ulna in an Elderly Lady.Journal of orthopaedic case reports · 2024Article
- Denosumab Re-Challenge and Long-Term Efficacy for Aneurysmal Bone Cyst of the Spine: Enhanced Treatment Algorithm.Journal of clinical medicine · 2024Article
- Response of Recurrent Aggressive Aneurysmal Bone Cyst of Distal Tibia to Denosumab Treatment.Journal of orthopaedic case reports · 2024Article
- Modern treatment of unicameral and aneurysmatic bone cysts.EFORT open reviews · 2024Review
- Pathological Fractures in Aneurysmal Bone Cysts: A Systematic Review.Journal of clinical medicine · 2024Review
- Management of RANKL-mediated Disorders With Denosumab in Children and Adolescents: A Global Expert Guidance Document.The Journal of clinical endocrinology and metabolism · 2024Article
- Denosumab and sclerotherapy for recurrent spinal aneurysmal bone cyst in a child.BMJ case reports · 2024Article
- Using Denosumab as a Nonsurgical Management of Aneurysmal Bone Cysts in the Pelvis.Clinics in orthopedic surgery · 2024Article
- Current indications for denosumab in benign bone tumours.EFORT open reviews · 2023Review
- Sclerotherapy as a primary or salvage procedure for aneurysmal bone cysts: A single-center experience.World journal of orthopedics · 2023Article
- Denosumab-Induced Rebound Hypercalcemia Treated With Bisphosphonates in a Pediatric Patient.JCEM case reports · 2023Article
- Surgical Management and Denosumab for Aneurysmal Bone Cysts of the Spine in an Australian Tertiary Paediatric Centre.Calcified tissue international · 2023Article
- Aneurysmal Bone Cyst (ABC) of the C2 Vertebra.Cureus · 2022Article
- Doxycycline sclerotherapy of cervical spine aneurysmal bone cysts: single-institution 13-year experience.Pediatric radiology · 2022Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose: Aneurysmal bone cyst (ABC) is a rare skeletal tumor usually treated with surgery/embolization. We hypothesized that owing to similarities with giant cell tumor of bone (GCTB), denosumab was active also in ABC.
methods: In this observational study, a retrospective analysis of ABC patients treated with denosumab was performed. Patients underwent radiologic disease assessment every 3 months. Symptoms and adverse events were noted.
results: Nine patients were identified (6 male, 3 female), with a median age of 17 years (range 14-42 years). Primary sites were 6 spine-pelvis, 1 ulna, 1 tibia, and 1 humerus. Patients were followed for a median time of 23 months (range 3-55 months). Patients received a median of 8 denosumab administrations (range 3-61). All symptomatic patients had pain relief and 1 had paresthesia improvement. Signs of denosumab activity were observed after 3 to 6 months of administration: bone formation by computed tomography scan was demonstrated in all patients and magnetic resonance imaging gadolinium contrast media decrease was observed in 7/9 patients. Adverse events were negligible. At last follow-up, all patients were progression-free: 5 still on denosumab treatment, 2 off denosumab were disease-free 11 and 17 months after surgery, and the last 2 patients reported no progression 12 and 24 months after denosumab interruption and no surgery.
conclusions: Denosumab has substantial activity in ABCs, with favorable toxicity profile. We strongly support the use of surgery and/or embolization for the treatment of ABC, but denosumab could have a role as a therapeutic option in patients with uncontrollable, locally destructive, or recurrent disease.
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Registered trials
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