Evidence map›Paper›PMID 30086659›Full record

Trial reportUpsala journal of medical sciences2018

The effect of group-based cognitive behavioral therapy on inflammatory biomarkers in patients with coronary heart disease-results from the SUPRIM-trial.

Erik M G Olsson, Fredrika Norlund, Ronnie Pingel, Gunilla Burell, Mats Gulliksson, Anders Larsson, Bo Karlsson, Kurt Svärdsudd, Claes Held

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Upsala journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Erik M G Olssona Department of Women's and Children's Health , Uppsala University , Uppsala , Sweden.ORCID http://orcid.org/0000-0002-1591-7407
Fredrika Norlunda Department of Women's and Children's Health , Uppsala University , Uppsala , Sweden.ORCID http://orcid.org/0000-0001-8895-5247
Ronnie Pingelb Department of Public Health and Caring Sciences , Uppsala University , Uppsala , Sweden.ORCID http://orcid.org/0000-0002-4140-1981
Gunilla Burellb Department of Public Health and Caring Sciences , Uppsala University , Uppsala , Sweden.ORCID http://orcid.org/0000-0002-8258-8703
Mats Gullikssonb Department of Public Health and Caring Sciences , Uppsala University , Uppsala , Sweden.ORCID http://orcid.org/0000-0002-0517-470X
Anders Larssonc Department of Medical Sciences, Biomedical Structure and Function , Uppsala University , Uppsala , Sweden.ORCID http://orcid.org/0000-0003-3161-0402
Bo Karlssonb Department of Public Health and Caring Sciences , Uppsala University , Uppsala , Sweden.ORCID http://orcid.org/0000-0002-4566-5079
Kurt Svärdsuddb Department of Public Health and Caring Sciences , Uppsala University , Uppsala , Sweden.ORCID http://orcid.org/0000-0002-8925-9670
Claes Helda Department of Women's and Children's Health , Uppsala University , Uppsala , Sweden.ORCID http://orcid.org/0000-0001-9402-7404

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Secondary Prevention in Uppsala Primary Healthcare Project (SUPRIM) is a prospective randomized controlled trial of a group-based cognitive behavioral therapy (CBT) stress management program for coronary heart disease (CHD) patients. The intervention reduced the risk of fatal or non-fatal first recurrent cardiovascular (CV) events. The aim of the present study was to analyze if the positive effects of the CBT program on clinical outcomes could have been mediated by changes in biomarkers for inflammation.

methodsAltogether 362 patients with CHD were randomly assigned to intervention or usual care. The inflammatory biomarkers (VCAM-1, TNF-R1, TNF-R2, PTX3, and hs-CRP) were serially assessed at five time points every six months from study start until 24 months later, and analyzed with linear mixed models.

resultsBaseline levels of the inflammatory markers were near normal, indicating a stable phase. The group-based CBT stress management program did not significantly affect the levels of inflammatory biomarkers in patients with CHD. Three out of five (VCAM-1, TNF-R2, and PTX3) inflammatory biomarkers showed a slight increase over time in both study groups, and all were positively associated with age.

conclusionGroup-based CBT stress management did not affect biomarkers for inflammation in patients with CHD. It is therefore unlikely that inflammatory processes including these biomarkers were mediating the effect the CBT program had on the reduction in CV events. The close to normal baseline levels of the biomarkers and the lack of elevated psychological distress symptoms indicate a possible floor effect which may have influenced the results.

Indexed as

Psychotherapy, GroupAgedBiomarkersCognitive Behavioral TherapyCoronary Artery BypassCoronary DiseaseFemaleHumansInflammationLinear ModelsMaleMiddle AgedPercutaneous Coronary InterventionStress, PsychologicalTime FactorsTreatment OutcomeBiomarkersBiomarkersCBTCHDinflammationstress management

Identifiers

PMID30086659
PMCPMC6198612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.