Evidence map›Paper›PMID 30086657›Full record

ArticleInhalation toxicology

A new cell culture exposure system for studying the toxicity of volatile chemicals at the air-liquid interface.

Jose Zavala, Allen D Ledbetter, David S Morgan, Lisa A Dailey, Earl Puckett, Shaun D McCullough, Mark Higuchi

Abstract read
In one paragraph

Article in Inhalation toxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Bionic breathing-type airway exposure system for inhalation exposure studies.Frontiers in bioengineering and biotechnology · 2026
    Article
  2. New approach methodologies (NAMs) for theFrontiers in toxicology · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency.Toxicological sciences : an official journal of the Society of Toxicology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jose Zavalaa NHEERL , U.S. Environmental Protection Agency, Research Triangle Park , NC , USA.ORCID 0000-0001-8286-6577
Allen D Ledbettera NHEERL , U.S. Environmental Protection Agency, Research Triangle Park , NC , USA.
David S Morganb NHEERL, U.S. Environmental Protection Agency , Chapel Hill , NC , USA.
Lisa A Daileyb NHEERL, U.S. Environmental Protection Agency , Chapel Hill , NC , USA.
Earl Pucketta NHEERL , U.S. Environmental Protection Agency, Research Triangle Park , NC , USA.
Shaun D McCulloughb NHEERL, U.S. Environmental Protection Agency , Chapel Hill , NC , USA.
Mark Higuchia NHEERL , U.S. Environmental Protection Agency, Research Triangle Park , NC , USA.

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

A cell culture exposure system (CCES) was developed to expose cells established at an air-liquid interface (ALI) to volatile chemicals. We characterized the CCES by exposing indigo dye-impregnated filter inserts inside culture wells to 125 ppb ozone (O

Indexed as

AcroleinBiomarkersBronchiCells, CulturedEpithelial CellsHeme Oxygenase-1HumansInhalation ExposureInterleukin-8L-Lactate DehydrogenaseRisk AssessmentSpectrometry, FluorescenceToxicity TestsVolatile Organic CompoundsVolatilizationAcroleinBiomarkersCXCL8 protein, humanHeme Oxygenase-1HMOX1 protein, humanInterleukin-8L-Lactate DehydrogenaseVolatile Organic CompoundsacroleinAir–liquid interfaceair pollutionin vitro exposuretoxicity screeningvolatile organic compounds

Identifiers

PMID30086657
PMCPMC6516487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.