ArticleCortex; a journal devoted to the study of the nervous system and behavior2018
Boundary extension is attenuated in patients with ventromedial prefrontal cortex damage.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Contextual Modulation of Semantic Coherence in vmPFC Patients' Mental Constructions.Entropy (Basel, Switzerland) · 2026Article
- The detection of episodic memory in others biases social choice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- From single scenes to extended scenarios: The role of the ventromedial prefrontal cortex in the construction of imagery-rich events.PloS one · 2026Article
- A generative model of memory construction and consolidation.Nature human behaviour · 2024Article
- Article
- Characterising the hippocampal response to perception, construction and complexity.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- An asymmetry in past and future mental time travel following vmPFC damage.Social cognitive and affective neuroscience · 2021Article
- Scene processing following damage to the ventromedial prefrontal cortex.Neuroreport · 2019Article
- Lesion Studies in Contemporary Neuroscience.Trends in cognitive sciences · 2019Review
- The Neural Dynamics of Novel Scene Imagery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Imagining Events Alternative to the Present Can Attenuate Delay Discounting.Frontiers in behavioral neuroscience · 2019Article
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Authors and funding
6 authors.
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Abstract
The ventromedial prefrontal cortex (vmPFC) and hippocampus have been implicated in the mental construction of scenes and events. However, little is known about their specific contributions to these cognitive functions. Boundary extension (BE) is a robust indicator of fast, automatic, and implicit scene construction. BE occurs when individuals who are viewing scenes automatically imagine what might be beyond the view, and consequently later misremember having seen a greater expanse of the scene. Patients with hippocampal damage show attenuated BE because of their scene construction impairment. In the current study, we administered BE tasks to patients with vmPFC damage, brain-damaged control patients, and healthy control participants. We also contrasted the performance of these patients to the previously-published data from patients with hippocampal lesions (Mullally, Intraub, & Maguire, 2012). We found that vmPFC-damaged patients showed reduced BE compared to brain-damaged and healthy controls. Indeed, BE attenuation was similar following vmPFC or hippocampal damage. Notably, however, whereas hippocampal damage seems to particularly impair the spatial coherence of scenes, vmPFC damage leads to a difficulty constructing scenes in a broader sense, with the prediction of what should be in a scene, and the monitoring or integration of the scene elements being particularly compromised. We conclude that vmPFC and hippocampus play important and complementary roles in scene construction.
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