ArticleACS applied materials & interfaces2018
Nanofunctionalized Stent-Mediated Local Heat Treatment for the Suppression of Stent-Induced Tissue Hyperplasia.
Article in ACS applied materials & interfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Late Obstruction After Esophageal Self-Expandable Metallic Stent Placement for Malignant Stenosis or Fistula: Epithelial Hyperplasia as a Common Cause.Digestive diseases and sciences · 2026Article
- Study on the antibacterial activity and biocompatibility of nano-silver/carbon nanotube composite coatings on airway stents prepared by micro-transfer printing.Scientific reports · 2025Article
- Hydrogel-Impregnated Robust Interlocking Nano Connector (HiRINC) for Noninvasive Anti-Migration of Esophageal Stent.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Endoluminal photodynamic therapy with a photoreactive stent-based catheter system to treat malignant colorectal obstruction.Bioengineering & translational medicine · 2025Article
- Biofunctional coatings and drug-coated stents for restenosis therapy.Materials today. Bio · 2024Review
- Drug Delivery Opportunities in Esophageal Cancer: Current Treatments and Future Prospects.Molecular pharmaceutics · 2024Review
- 3D-printed versatile biliary stents with nanoengineered surface for anti-hyperplasia and antibiofilm formation.Bioactive materials · 2024Article
- Local hyperthermia mediated by gold nanoparticle-integrated silicone-covered stent: feasibility and tissue response in a rat esophageal model.European radiology experimental · 2024Article
- Study on the rationality of small diameter metallic airway stent in treatment of tracheal stenosis in injured rabbits.Journal of cardiothoracic surgery · 2024Article
- Radiofrequency ablation via an implanted self-expandable metallic stent to treat in-stent restenosis in a rat gastric outlet obstruction model.Frontiers in bioengineering and biotechnology · 2023Article
- Tapered self-expandable metallic stent optimized for Eustachian tube morphology in a porcine ET model.Scientific reports · 2022Article
- Synergistic effects of silver nanoparticles and cisplatin in combating inflammation and hyperplasia of airway stents.Bioactive materials · 2022Article
- Silver Nanofunctionalized Stent after Radiofrequency Ablation Suppresses Tissue Hyperplasia and Bacterial Growth.Pharmaceutics · 2022Article
- Recent progress in cryoablation cancer therapy and nanoparticles mediated cryoablation.Theranostics · 2022Review
- Silver nanoparticle-coated self-expandable metallic stent suppresses tissue hyperplasia in a rat esophageal model.Surgical endoscopy · 2022Article
- Photothermal therapy via a gold nanoparticle-coated stent for treating stent-induced granulation tissue formation in the rat esophagus.Scientific reports · 2021Article
- Article
- Advances in stent therapy for malignant biliary obstruction.Abdominal radiology (New York) · 2021Review
- Metallic Stent Mesh Coated with Silver Nanoparticles Suppresses Stent-Induced Tissue Hyperplasia and Biliary Sludge in the Rabbit Extrahepatic Bile Duct.Pharmaceutics · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Current therapeutic strategies are insufficient for suppressing stent-induced restenosis. Here, branched gold nanoparticles (BGNP)-coated self-expandable metallic stents (SEMSs) were developed for a local heat-induced suppression of stent-related tissue hyperplasia. Our polydopamine (PDA) coating on SEMS allowed BGNP crystal growth on the surface of SEMSs. The prepared BGNP-coated SEMS showed effective local heating under near-infrared laser irradiation. The effectiveness of BGNP-coated SEMSs for suppressing stent-related tissue hyperplasia was demonstrated in a rat esophageal model ( n = 52). BGNP-coated SEMS placement under fluoroscopic guidance was technically successful in all rats. The placed BGNP-coated SEMS in rat esophagus achieved three different local heat dose ranges (50, 65, and 80 °C) under fluoroscopic image-guided local irradiation. Follow-up endoscopic examination readily monitored the local heating and observed significantly decreased tissue hyperplasia at 4 weeks of local heat treatments (50 and 65 °C). Finally, Western blot, histology, immunohistochemistry (HSP70, αSMA, and TUNEL), and immunofluorescence (Ki67 and BrdU) analyses along with the statistical analysis confirmed that optimized BGNP-coated SEMS-mediated local heat treatments inducing the expression of anti-inflammatory HSP70 effectively suppresses tissue hyperplasia after stent placement in the esophagus. Our local heating with nanofunctionalized stents represents a promising new approach for suppressing stent-related tissue hyperplasia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.