Evidence map›Paper›PMID 30086198›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2018

Living donor postnephrectomy kidney function and recipient graft loss: A dose-response relationship.

Courtenay M Holscher, Tanveen Ishaque, Jacqueline M Garonzik Wang, Christine E Haugen, Sandra R DiBrito, Kyle R Jackson, Abimereki D Muzaale, Allan B Massie, Fawaz Al Ammary, Shane E Ottman and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Correlation of preoperative imaging characteristics with donor outcomes and operative difficulty in laparoscopic donor nephrectomy.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Courtenay M HolscherDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5808-5954
Tanveen IshaqueDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jacqueline M Garonzik WangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christine E HaugenDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-5884-2604
Sandra R DiBritoDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kyle R JacksonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abimereki D MuzaaleDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-3287-6061
Allan B MassieDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Fawaz Al AmmaryDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shane E OttmanDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Macey L HendersonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-4239-1252
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USNational Marrow Donor Program · US

Funding

Long-Term Health Outcomes After Live Kidney Donation in African AmericansR01DK096008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.8M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
Technological Innovations for Live Kidney Donor Follow-up Care ManagementK01DK114388 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LEVAN, MACEY LEIGH · 2017 to 2021
$720k
Differential Survival Benefit of Incompatible Living Donor Kidney Transplantation: Modeling Outcomes for Different Patient PhenotypesF32DK113719 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JACKSON, KYLE R · 2017 to 2019
$238k
Trajectory of post-donation renal function in living kidney donorsF32DK109662 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HOLSCHER, COURTENAY · 2016 to 2018
$232k
Health Care Utilization and Race: Live Kidney Donor Risks and OutcomesF32DK105600 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DIBRITO, SANDRA RENAE · 2015 to 2017
$227k
Novel Frailty Phenotype in Older Adults with End-Stage Renal DiseaseF32AG053025 · NIA · JOHNS HOPKINS UNIVERSITY · PI HAUGEN, CHRISTINE · 2016 to 2019
$204k
NIA NIH HHS F32 AG053025NIA NIH HHS F32AG053025NIDDK NIH HHS F32 DK105600NIDDK NIH HHS F32DK105600NIDDK NIH HHS F32 DK109662NIDDK NIH HHS F32DK109662NIDDK NIH HHS F32 DK113719NIDDK NIH HHS F32DK113719NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K01DK101677NIDDK NIH HHS K01 DK114388NIDDK NIH HHS K01DK114388NIDDK NIH HHS K24 DK101828NIDDK NIH HHS K24DK101828NIDDK NIH HHS R01 DK096008
6 · The paper itself

Abstract

Development of end-stage renal disease (ESRD) in living kidney donors is associated with increased graft loss in the recipients of their kidneys. Our goal was to investigate if this relationship was reflected at an earlier stage postdonation, possibly early enough for recipient risk prediction based on donor response to nephrectomy. Using national registry data, we studied 29 464 recipients and their donors from 2008-2016 to determine the association between donor 6-month postnephrectomy estimated GFR (eGFR) and recipient death-censored graft failure (DCGF). We explored donor BMI as an effect modifier, given the association between obesity and hyperfiltration. On average, risk of DCGF increased with each 10 mL/min decrement in postdonation eGFR (adjusted hazard ratio [aHR] 1.06, 95% confidence interval [CI] 1.02-1.10, P = .007). The association was attenuated with higher donor BMI (interaction P = .049): recipients from donors with BMI = 20 (aHR 1.12, 95% CI 1.04-1.19, P = .002) and BMI = 25 (aHR 1.07, 95% CI 1.03-1.12, P = .001) had a higher risk of DCGF with each 10 mL/min decrement in postdonation eGFR, whereas recipients from donors with BMI = 30 and BMI = 35 did not have a higher risk. The relationship between postdonation eGFR, donor BMI, and recipient graft loss can inform counseling and management of living donor kidney transplant recipients.

Indexed as

Glomerular Filtration RateAdultFemaleFollow-Up StudiesGraft RejectionGraft SurvivalHumansKidney Failure, ChronicKidney Function TestsKidney TransplantationLiving DonorsMaleMiddle AgedNephrectomyPostoperative ComplicationsPrognosisdonors and donation: livinggraft survivalhealth services and outcomes researchkidney transplantation: living donorkidney transplantation/nephrology

Identifiers

PMID30086198
PMCPMC6219620
OpenAlexW2886120549

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.