Evidence map›Paper›PMID 30086139›Full record

ArticlePLoS medicine2018

Choices in vaccine trial design in epidemics of emerging infections.

Rebecca Kahn, Annette Rid, Peter G Smith, Nir Eyal, Marc Lipsitch

Abstract read
In one paragraph

Article in PLoS medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. On BCG Vaccine Protection from COVID-19: A Review.SN comprehensive clinical medicine · 2021
    Review
  13. Article
  14. Review
  15. Opinion: It's ethical to test promising coronavirus vaccines against less-promising ones.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Article
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rebecca KahnCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Annette RidDepartment of Global Health & Social Medicine, King's College London, London, United Kingdom.ORCID 0000-0003-1117-1975
Peter G SmithMRC Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0003-0080-7560
Nir EyalDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.ORCID 0000-0003-1056-6609
Marc LipsitchCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.ORCID 0000-0003-1504-9213

Funding

Understanding and controlling antibiotic resistanceU54GM088558 · NIGMS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HANAGE, WILLIAM · 2009 to 2018
$26.4M
Medical Research Council MR/K012126/1NIGMS NIH HHS U54 GM088558Wellcome TrustWellcome Trust 208766/Z/17/Z
6 · The paper itself

Abstract

In a Policy Forum, Marc Lipsitch and colleagues discuss trial design issues in infectious disease outbreaks.

Indexed as

EpidemicsCommunicable Diseases, EmergingDouble-Blind MethodDrugs, InvestigationalEbola VaccinesEthics, ResearchFeasibility StudiesHemorrhagic Fever, EbolaHumansPlacebosRandomized Controlled Trials as TopicResearch DesignVaccinesDrugs, InvestigationalEbola VaccinesPlacebosVaccines

Identifiers

PMID30086139
PMCPMC6080746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.