Evidence map›Paper›PMID 30086127›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2018

Upregulated hsa_circ_0004458 Contributes to Progression of Papillary Thyroid Carcinoma by Inhibition of miR-885-5p and Activation of RAC1.

Xiaoyan Jin, Zhengyi Wang, Wenyang Pang, Jian Zhou, Yong Liang, Jingjin Yang, Linjun Yang, Qiang Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. The Changing Face ofFrontiers in surgery · 2020
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  18. CircRNA: A novel potential strategy to treat thyroid cancer (Review).International journal of molecular medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaoyan JinDepartment of Surgical Oncology, Zhejiang Taizhou Municipal Hospital, Taizhou, Zhejiang, China (mainland).
Zhengyi WangDepartment of Surgical Oncology, Zhejiang Taizhou Municipal Hospital, Taizhou, Zhejiang, China (mainland).
Wenyang PangDepartment of Surgical Oncology, Zhejiang Taizhou Municipal Hospital, Taizhou, Zhejiang, China (mainland).
Jian ZhouDepartment of Surgical Oncology, Zhejiang Taizhou Municipal Hospital, Taizhou, Zhejiang, China (mainland).
Yong LiangDepartment of Clinical Laboratory, Medical School, Taizhou University, Taizhou, Zhejiang, China (mainland).
Jingjin YangSchool of Medicine, Taizhou University, Taizhou, Zhejiang, China (mainland).
Linjun YangDepartment of Surgical Oncology, Zhejiang Taizhou Municipal Hospital, Taizhou, Zhejiang, China (mainland).
Qiang ZhangDepartment of Surgical Oncology, Zhejiang Taizhou Municipal Hospital, Taizhou, Zhejiang, China (mainland).
Taizhou Municipal Hospital · CNTaizhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Circular RNAs (circRNAs), a class of noncoding RNAs, may act as biomarkers and therapeutic targets of various cancers. However, the effects of hsa_circ_0004458 in papillary thyroid carcinoma (PTC) are still very much unclear. We aimed to demonstrate the potential roles of hsa_circ_0004458 in the progression of PTC. MATERIAL AND METHODS In our study, qRT-PCR assay was performed to assess hsa_circ_0004458, miR-885-5p and RAC1 expressions. Dual-luciferase reporter assay was used to detect the regulatory effects of hsa_circ_0004458 on miR-885-5p, and miR-885-5p on RAC1. MTT and flow cytometry assays were used to measure the cell proliferation, cycle, and apoptosis abilities. Tumor formation assay in nude mice was performed to measure the tumor growth in vivo. RESULTS Our results indicated that hsa_circ_0004458 was upregulated in PTC tissues and cells, while silencing of hsa_circ_0004458 suppressed PTC cell proliferation and promoted PTC cell cycle arrest and apoptosis in vitro. Tumor formation assay in nude mice showed that knockdown of hsa_circ_0004458 by siRNAs inhibited the growth of PTC tumor in vivo. In addition, we found that miR-885-5p was a direct target of hsa_circ_0004458, and silencing of hsa_circ_0004458 inhibited PTC cell proliferation by miR-885-5p. We also demonstrated that RAC1 was a direct target of miR-885-5p and silencing of RAC1 suppressed PTC cell proliferation. CONCLUSIONS We found that hsa_circ_0004458 promoted the progression of PTC by inhibition of miR-885-5p and activation of RAC1, and hsa_circ_0004458 may serve as a potential therapeutic target and biomarker for PTC.

Indexed as

AdultAgedAnimalsApoptosisCell Line, TumorCell ProliferationFemaleHeterograftsHumansMaleMiceMice, Inbred BALB CMice, NudeMicroRNAsMiddle Agedrac1 GTP-Binding ProteinMicroRNAsMIRN885 microRNA, humanrac1 GTP-Binding ProteinRAC1 protein, humanRNARNA, Circular

Identifiers

PMID30086127
PMCPMC6094983
OpenAlexW2885734570

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.