Evidence map›Paper›PMID 30085416›Full record

ArticleStem cells translational medicine2018

Amniotic Fluid Stem Cells for the Treatment of Surgical Disorders in the Fetus and Neonate.

Shaun M Kunisaki

Open access · goldAbstract read
In one paragraph

Article in Stem cells translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Amniotic Fluid Stem Cells: What They Are and What They Can Become.Current stem cell research & therapy · 2023
    Article
  6. Amniotic fluid characteristics and its application in stem cell therapy: A review.International journal of reproductive biomedicine · 2022
    Review
  7. Review
  8. Article
  9. Article
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  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Shaun M KunisakiDepartment of Surgery, Fetal Diagnosis and Treatment Center and Section of Pediatric Surgery, University of Michigan, C.S. Mott Children's and Von Voigtlander Women's Hospital, Ann Arbor, Michigan, USA.ORCID 0000-0002-9229-4733
University of Michigan–Ann Arbor · US

Funding

Stem cell-based biomaterials for spinal regeneration in neural tube defectsR01HD091323 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KUNISAKI, SHAUN MICHAEL · 2017 to 2021
$1.6M
NICHD NIH HHS R01 HD091323
6 · The paper itself

Abstract

Over the past decade, amniotic fluid-derived stem cells have emerged as a novel experimental approach aimed at improving outcomes in children with congenital anomalies, including spina bifida, heart defects, and diaphragmatic hernia. Interest in these cells for the treatment of prenatally diagnosed diseases has arisen based on numerous studies demonstrating the relative ease of harvesting an abundant quantity of amniocytes from a small aliquot of fluid, the unique properties of amniocytes themselves, and the beneficial effects of amniotic fluid-derived stem cells in experimental animal models. This report gives a brief overview of the rationale and current status of amniotic fluid stem cell-based therapies, focusing on its relevance to birth defects affecting the fetus and neonate. The author proposes a roadmap for further study that would be required prior to clinical application of amniotic fluid stem cell technologies. Stem Cells Translational Medicine 2018;7:767-773.

Indexed as

Stem Cell TransplantationAmniotic FluidFetal DiseasesHeart Defects, CongenitalHumansInduced Pluripotent Stem CellsInfant, NewbornMyocytes, CardiacSpinal DysraphismStem CellsTissue Engineering

Identifiers

PMID30085416
PMCPMC6216434
OpenAlexW2886978846

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.