Evidence map›Paper›PMID 30085414›Full record

ArticleMicrobiologyOpen2019

Purification and characterization of FtsZ from the citrus canker pathogen Xanthomonas citri subsp. citri.

Malgorzata M Kopacz, André S G Lorenzoni, Carlos R Polaquini, Luis O Regasini, Dirk-Jan Scheffers

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MicrobiologyOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Antagonistic transcriptome profile reveals potential mechanisms of action onFrontiers in cellular and infection microbiology · 2023
    Article
  2. Article
  3. Design of Antibacterial Agents: Alkyl Dihydroxybenzoates againstInternational journal of molecular sciences · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Malgorzata M KopaczDepartment of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.
André S G LorenzoniDepartment of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.
Carlos R PolaquiniLaboratory of Antibiotics and Chemotherapeutics, Department of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, SP, Brazil.
Luis O RegasiniLaboratory of Antibiotics and Chemotherapeutics, Department of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, SP, Brazil.
Dirk-Jan ScheffersDepartment of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-9439-9168
University of Groningen · NLUniversidade Estadual Paulista (Unesp) · BR

Funding

ISOLATION OF CLONES: TYPE III PROCOLLAGEN N-PROTEINASEF05TW004005 · FIC · THOMAS JEFFERSON UNIVERSITY · PI HALILA, RITVA · 1987 to 1988
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6 · The paper itself

Abstract

Xanthomonas citri subsp. citri (Xac) is the causative agent of citrus canker, a plant disease that significantly impacts citriculture. In earlier work, we showed that alkylated derivatives of gallic acid have antibacterial action against Xac and target both the cell division protein FtsZ and membrane integrity in Bacillus subtilis. Here, we have purified native XacFtsZ and characterized its GTP hydrolysis and polymerization properties. In a surprising manner, inhibition of XacFtsZ activity by alkyl gallates is not as strong as observed earlier with B. subtilis FtsZ. As the alkyl gallates efficiently permeabilize Xac membranes, we propose that this is the primary mode of antibacterial action of these compounds.

Indexed as

Anti-Bacterial AgentsBacterial ProteinsCell MembraneCitrusCytoskeletal ProteinsEnzyme InhibitorsGallic AcidGuanosine TriphosphateHydrolysisPlant DiseasesProtein MultimerizationXanthomonasAnti-Bacterial AgentsBacterial ProteinsCytoskeletal ProteinsEnzyme InhibitorsFtsZ protein, BacteriaGallic AcidGuanosine Triphosphateantibacterialscell divisionFtsZgallatesgallic acidGTPasemembrane permeabilization

Identifiers

PMID30085414
PMCPMC6528577
OpenAlexW2886961170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.