ArticleFEMS microbiology letters2018
Dysbiosis and early mortality in zebrafish larvae exposed to subclinical concentrations of streptomycin.
Article in FEMS microbiology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Gut Microbiome of Aquatic Organisms: Role in Immunity Formation and Effects on Aquaculture Productivity.Microorganisms · 2026Review
- Phenotypic heterogeneity in Pseudomonas aeruginosa virulence revealed through passive exposure in zebrafish (Danio rerio) and nematodes (Caenorhabditis elegans).Access microbiology · 2026Article
- The Role ofToxics · 2025Review
- Longitudinal study on the effects of a synbiotic supplement to Atlantic salmon diets on performance, gut microbiota and immune responses during antibiotic treatment and subsequent recovery.Animal microbiome · 2024Article
- Defining the environmental determinants of dysbiosis at scale with zebrafish.Current opinion in toxicology · 2023Article
- Zebrafish: an efficient vertebrate model for understanding role of gut microbiota.Molecular medicine (Cambridge, Mass.) · 2022Review
- Application of zebrafish in the study of the gut microbiome.Animal models and experimental medicine · 2022Review
- Prior exposure to ciprofloxacin disrupts intestinal homeostasis and predisposes ayu (Zoological research · 2022Article
- Monitoring Infection and Antibiotic Treatment in the Skin Microbiota of Farmed European Seabass (Dicentrarchus Labrax) Fingerlings.Microbial ecology · 2022Article
- Establishment and evaluation of a specific antibiotic-induced inflammatory bowel disease model in rats.PloS one · 2022Article
- Heat Stress Weakens the Skin Barrier Function in Sturgeon by Decreasing Mucus Secretion and Disrupting the Mucosal Microbiota.Frontiers in microbiology · 2022Article
- Passive exposure to cannabidiol oil does not cause microbiome dysbiosis in larval zebrafish.Current research in microbial sciences · 2021Article
- Article
- Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth-Deferiprone Therapy againstMicroorganisms · 2021Article
- Urbanization Constrains Skin Bacterial Phylogenetic Diversity in Wild Fish Populations and Correlates with the Proliferation of Aeromonads.Microbial ecology · 2021Article
- Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics.Pharmaceuticals (Basel, Switzerland) · 2021Review
- ProbioticNutrients · 2021Article
- Phylogenetic Integration Reveals the Zebrafish Core Microbiome and Its Sensitivity to Environmental Exposures.Toxics · 2021Article
- Mollusk microbiota shift during Angiostrongylus cantonensis infection in the freshwater snail Biomphalaria glabrata and the terrestrial slug Phillocaulis soleiformis.Parasitology research · 2020Article
- Partial Evaluation of Autochthonous Probiotic Potential of the Gut Microbiota of Seriola lalandi.Probiotics and antimicrobial proteins · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to low concentrations of antibiotics found in aquatic environments can increase susceptibility to infection in adult fish due to microbiome disruption. However, little is known regarding the effect of antibiotic pollution on fish larvae. Here, we show that exposure to streptomycin, a common antibiotic used in medicine and aquaculture, disrupts the normal composition of zebrafish larvae microbiomes, significantly reducing the microbial diversity found in the fish. Exposure to streptomycin also significantly increased early mortality among fish larvae, causing full mortality within a few days of exposure at 10 μg/mL. Finally, we found that subclinical concentrations of streptomycin also increased the abundance of class 1 integrons, an integrase-dependent genetic system associated to the horizontal transfer of antibiotic resistance genes, in the larvae microbiomes. These results suggest that even low concentrations of streptomycin associated with environmental pollution could impact fish populations and lead to the creation of antibiotic resistance reservoirs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.