ArticleAmerican journal of epidemiology2018
Age at Exposure to Arsenic in Water and Mortality 30-40 Years After Exposure Cessation.
Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Interaction between Occupational and Non-Occupational Arsenic Exposure and Tobacco Smoke on Lung Cancerogenesis: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Arsenic exposure at birth, socioeconomic status, and epigenetic aging among adults in northern Chile.Environmental research · 2026Article
- Long-term effect of early-life arsenic exposure on morning plasma cortisol in adults from Antofagasta, Chile.Environmental health : a global access science source · 2026Article
- Evaluation of lung oxidative stress and inflammatory state using exhaled breath condensate analysis in early-life arsenic exposure.Journal of breath research · 2025Article
- Long-Term Effect of Early-Life Arsenic Exposure on Morning Plasma Cortisol in Adults from Antofagasta, Chile.medRxiv : the preprint server for health sciences · 2025Article
- Association of arsenic exposure with PDGF-BB in vitro and in a South Texas population exposed through drinking water.Toxicology and applied pharmacology · 2025Article
- Reported Behavioral Patterns and Concern Surrounding Well Water Testing for Arsenic in Midwestern Homeowners with Children.International journal of environmental research and public health · 2025Article
- Epidemiology of Pediatric Tumors in Quebec: A 17-Year Report of Cancer in Young People in the Canada Registry.Current oncology (Toronto, Ont.) · 2024Article
- An appraisal of the principal concerns and controlling factors for Arsenic contamination in Chile.Scientific reports · 2023Article
- Characterization of Arsenic and Atrazine Contaminations in Drinking Water in Iowa: A Public Health Concern.International journal of environmental research and public health · 2023Article
- miRNAs and arsenic-induced carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023Review
- Comparative Biomonitoring of Arsenic Exposure in Mothers and Their Neonates in Comarca Lagunera, Mexico.International journal of environmental research and public health · 2022Article
- The association of arsenic exposure and arsenic metabolism with all-cause, cardiovascular and cancer mortality in the Strong Heart Study.Environment international · 2022Article
- The impact of prenatal and early-life arsenic exposure on epigenetic age acceleration among adults in Northern Chile.Environmental epigenetics · 2022Article
- Urinary arsenic and relative telomere length in 5-7 year old children in Bangladesh.Environment international · 2021Article
- Paradoxical effects of arsenic in the lungs.Environmental health and preventive medicine · 2021Review
- Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk.Scientific reports · 2021Article
- Single-cell RNA-seq Analysis Reveals That Prenatal Arsenic Exposure Results in Long-term, Adverse Effects on Immune Gene Expression in Response to Influenza A Infection.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Locus-Specific Differential DNA Methylation and Urinary Arsenic: An Epigenome-Wide Association Study in Blood among Adults with Low-to-Moderate Arsenic Exposure.Environmental health perspectives · 2020Article
- Health effects of arsenic exposure in Latin America: An overview of the past eight years of research.The Science of the total environment · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Arsenic in drinking water is known to cause cancer and noncancer diseases, but little is known about its association with age at exposure. Here, we investigated age at arsenic exposure and mortality in Antofagasta, Chile, 30-40 years after a distinct period of very high water arsenic concentrations (1958-1970). We calculated standardized mortality ratios (SMRs) comparing Antofagasta with the rest of Chile for 2001-2010 by sex and age at potential first exposure. A remarkable relationship with age at first exposure was found for bronchiectasis, with increased risk in adults 30-40 years after exposure being confined to those who were in utero (SMR = 11.7, 95% confidence interval (CI): 4.3, 25.4) or aged 1-10 years (SMR = 5.4, 95% CI: 1.1, 15.8) during the high-exposure period. Increased SMRs for lung, bladder, and laryngeal cancer were evident for exposures starting at all ages, but the highest SMRs were for exposures beginning at birth (for bladder cancer, SMR = 16.0 (95% CI: 10.3, 23.8); for laryngeal cancer, SMR = 6.8 (95% CI: 2.2, 15.8); for lung cancer, SMR = 3.8 (95% CI: 2.9, 4.9)). These findings suggest that interventions targeting early-life arsenic exposure could have major impacts in reducing long-term mortality due to arsenic 30-40 years after exposure ends.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.