Evidence map›Paper›PMID 30084829›Full record

ArticleDiabetes2018

The Dysregulation of the

Vasumathi Kameswaran, Maria L Golson, Mireia Ramos-Rodríguez, Kristy Ou, Yue J Wang, Jia Zhang, Lorenzo Pasquali, Klaus H Kaestner

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Vasumathi KameswaranDepartment of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA.
Maria L GolsonDepartment of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA.
Mireia Ramos-RodríguezProgram of Predictive and Personalized Medicine of Cancer, Department of Endocrinology, Germans Trias i Pujol University Hospital and Research Institute, Badalona, Spain.
Kristy OuDepartment of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA.
Yue J WangDepartment of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA.
Jia ZhangDepartment of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA.
Lorenzo PasqualiProgram of Predictive and Personalized Medicine of Cancer, Department of Endocrinology, Germans Trias i Pujol University Hospital and Research Institute, Badalona, Spain.
Klaus H KaestnerDepartment of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA kaestner@pennmedicine.upenn.edu.ORCID 0000-0002-1228-021X
University of Pennsylvania · USJosep Carreras Leukaemia Research Institute · ES

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3M
Regulation and function of the MEG3 locus in human beta-cellsR01DK088383 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI KAESTNER, KLAUS H · 2010 to 2018
$4.8M
Epigenetic Rejuvenation of Human Beta-CellsUC4DK104119 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GLASER, BENJAMIN, KAESTNER, KLAUS H · 2014 to 2014
$3.6M
NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK088383NIDDK NIH HHS UC4 DK104119
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is characterized by the inability of the insulin-producing β-cells to overcome insulin resistance. We previously identified an imprinted region on chromosome 14, the

Indexed as

DNA MethylationGene Expression RegulationPromoter Regions, GeneticAnimalsCalcium-Binding ProteinsCell LineCytokinesDiabetes Mellitus, Type 2DNA (Cytosine-5-)-Methyltransferase 1Enhancer Elements, GeneticEpigenesis, GeneticGenetic LociGreen Fluorescent ProteinsHomeobox Protein Nkx-2.2Homeodomain ProteinsHumansCalcium-Binding ProteinsCytokinesDLK1 protein, humanDNA (Cytosine-5-)-Methyltransferase 1Green Fluorescent ProteinsHomeobox Protein Nkx-2.2Homeodomain ProteinsIntercellular Signaling Peptides and ProteinsMEG3 non-coding RNA, humanMembrane ProteinsNKX2-2 protein, humanNkx2-2 protein, mouseNuclear ProteinsRecombinant Fusion ProteinsRepressor ProteinsRNA, Long NoncodingTgif1 protein, mouseTranscription Factors

Identifiers

PMID30084829
PMCPMC6110314
OpenAlexW2809830861

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.