Evidence map›Paper›PMID 30084296›Full record

ArticleNanomedicine (London, England)2018

Influences of nanocarrier morphology on therapeutic immunomodulation.

Molly Frey, Sharan Bobbala, Nicholas Karabin, Evan Scott

Open access · greenAbstract read
In one paragraph

Article in Nanomedicine (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
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  4. Unlocking Transplant Tolerance with Biomaterials.Advanced healthcare materials · 2025
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  7. Review
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  9. Review
  10. Polymer-Based Nanosystems-A Versatile Delivery Approach.Materials (Basel, Switzerland) · 2021
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Molly FreyInterdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL 60208, USA.
Sharan BobbalaDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Nicholas KarabinDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Evan ScottInterdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL 60208, USA.
Northwestern University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0M
Medical Scientist Training ProgramT32GM144295 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALAN R HAUSER · 2022 to 2026
$9.1M
Chemistry of Life Processes Predoctoral Training ProgramT32GM105538 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2013 to 2022
$2.7M
Development of combination immunotherapies for atherosclerotic inflammationDP2HL132390 · NHLBI · NORTHWESTERN UNIVERSITY · PI SCOTT, EVAN ALEXANDER · 2015 to 2015
$2.3M
NHLBI NIH HHS DP2 HL132390NIGMS NIH HHS T32 GM008152NIGMS NIH HHS T32 GM105538NIGMS NIH HHS T32 GM144295
6 · The paper itself

Abstract

Nanomaterials provide numerous advantages for the administration of therapeutics, particularly as carriers of immunomodulatory agents targeting specific immune cell populations during immunotherapy. While the physicochemical characteristics of nanocarriers have long been linked to their therapeutic efficacy and applications, focus has primarily been placed on assessing influences of size and surface chemistry. In addition to these materials properties, the nanostructure morphology, in other words, shape and aspect ratio, has emerged as an equally important feature of nanocarriers that can dictate mechanisms of endocytosis, biodistribution and degree of cytotoxicity. In this review, we will highlight how the morphological features of nanostructures influence the immune responses elicited during therapeutic immunomodulation.

Indexed as

antigen-presenting cellsbiodistributiondrug deliveryimmunomodulationimmunotherapynanocarriernanomaterialnanoparticletheranosticsvaccination

Identifiers

PMID30084296
PMCPMC7270889
OpenAlexW2885564016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.