ArticleHepatology research : the official journal of the Japan Society of Hepatology2019
Risk factors and outcomes of acute respiratory distress syndrome in critically ill patients with cirrhosis.
Article in Hepatology research : the official journal of the Japan Society of Hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The effect of diabetes on the risk and mortality of acute lung injury/acute respiratory distress syndrome: A meta-analysis.Medicine · 2019Pooled it
- Characteristics and prognosis of patients with cirrhosis presenting with acute respiratory distress syndrome: A bicentric retrospective study.Journal of intensive medicine · 2026Article
- Acute-on-Chronic Liver Failure-Current Management and Future Perspectives.Biomedicines · 2025Review
- Review
- Association Between Platelet-Albumin-Bilirubin Grade and the 30-Day Mortality in Patients with Acute Respiratory Distress Syndrome: Evidence from the MIMIC-IV Database.Balkan medical journal · 2025Article
- Pulmonary Surfactant in Adult ARDS: Current Perspectives and Future Directions.Diagnostics (Basel, Switzerland) · 2023Review
- Intermediate tidal volume is an acceptable option for ventilated patients with acute respiratory distress syndrome.Medicina intensiva · 2022Article
- Intermediate tidal volume is an acceptable option for ventilated patients with acute respiratory distress syndrome.Medicina intensiva · 2022Article
- Total bilirubin is associated with all-cause mortality in patients with acute respiratory distress syndrome: a retrospective study.Annals of translational medicine · 2022Article
- Alcoholic liver disease: a new insight into the pathogenesis of liver disease.Archives of pharmacal research · 2022Review
- Tumor necrosis factor-α requires Ezrin to regulate the cytoskeleton and cause pulmonary microvascular endothelial barrier damage.Microvascular research · 2021Article
- Liver-lung interactions in acute respiratory distress syndrome.Intensive care medicine experimental · 2020Article
- Serum ionised calcium and the risk of acute respiratory failure in hospitalised patients: a single-centre cohort study in the USA.BMJ open · 2020Article
- Pulmonary complications in liver disease.Intensive care medicine · 2019Article
- Outcomes of Acute Respiratory Distress Syndrome in Mechanically Ventilated Patients With Cirrhosis.Critical care explorations · 2019Article
- Pulmonary Assessment of the Liver Transplant Recipient.Journal of clinical and experimental hepatologyReview
- Factors affecting the outcomes in patients with acute respiratory distress syndrome in a tertiary care setting.Clinical epidemiology and global healthArticle
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4 authors at 2 institutions in 1 country.
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Abstract
aimPrior randomized controlled trials of acute respiratory distress syndrome (ARDS) excluded critically ill patients with cirrhosis. Data regarding risk factors for ARDS development and outcomes from ARDS in patients with cirrhosis are scarce. We sought to characterize outcomes from ARDS in patients with cirrhosis.
methodsAn observational cohort of patients with cirrhosis admitted to an intensive care unit at a high-volume liver transplant center between 1 January 2012 and 31 December 2014 were reviewed. ARDS cases were identified according to the Berlin definition. Potential risk factors were examined in multivariable logistic regression analysis for ARDS development. Outcomes including in-hospital mortality were compared between ARDS and non-ARDS patients.
resultsA total of 559 patients met the inclusion criteria and 45 (8.1%) developed ARDS. Differences between ARDS and non-ARDS patients included sepsis, Model for End-Stage Liver Disease - Sodium score, and Sequential Organ Failure Assessment score. In-hospital mortality was higher in cirrhotic patients with ARDS compared with those without ARDS (82.2% vs. 27.6%, P < 0.001). In multivariable analysis, acute-on-chronic liver failure (OR 8.69, 95% CI 2.28-33.18, P < 0.01) and shock on intensive care unit admission (OR 3.13, 95% CI 1.57-6.24, P = 0.001) were associated with ARDS development, whereas etiology of cirrhosis or alcohol use were not.
conclusionsAcute-on-chronic liver failure and shock on intensive care unit admission were risk factors for ARDS development, whereas etiology of cirrhosis and alcohol were not. Mortality from ARDS was markedly increased in patients with cirrhosis. Early recognition and treatment for infection might be important for improving the high mortality in this group of patients.
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