Evidence map›Paper›PMID 30084150›Full record

ArticleHIV medicine2018

CD4:CD8 ratio in children with perinatally acquired HIV-1 infection.

T Seers, P Vassallo, K Pollock, J P Thornhill, S Fidler, C Foster

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HIV medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

T SeersFaculty of Medicine, Imperial College London, London, UK.ORCID 0000-0001-5955-4014
P VassalloFaculty of Medicine, Imperial College London, London, UK.
K PollockFaculty of Medicine, Imperial College London, London, UK.
J P ThornhillFaculty of Medicine, Imperial College London, London, UK.
S FidlerFaculty of Medicine, Imperial College London, London, UK.
C FosterImperial College Healthcare NHS Trust, London, UK.ORCID 0000-0001-8278-8564
Imperial College Healthcare NHS Trust · GBImperial College London · GB

Funding

Medical Research Council MR/N001265/1
6 · The paper itself

Abstract

objectivesIn adults with horizontally acquired HIV infection, an inverted CD4:CD8 ratio is associated with persistent immune activation, size of HIV reservoir and predicts an increased risk of non-AIDS-defining adverse events. Normalization of this ratio with antiretroviral therapy (ART) is suboptimal in adults, despite viral suppression, and is less well described in paediatric populations. We investigated rates of CD4:CD8 ratio recovery in children with perinatally acquired HIV infection (PaHIV) on ART.

methodsA cross-sectional, retrospective analysis of routine clinical data in children with PaHIV (5-18 years old) attending a single UK centre was carried out.

resultsCD4:CD8 normalization was seen in 62% of children on suppressive ART. A negative correlation was found between current CD4:CD8 ratio and age at start of ART. Positive correlations were found between current CD4:CD8 ratio and total time with suppressed HIV viral load and nadir CD4 counts. Multiple linear regression analysis showed that age at start of ART was significantly associated with current CD4:CD8 ratio (standardized β = -0.680; P < 0.001). Patient sex, ethnicity and antiretroviral regimen did not affect ratio recovery.

conclusionsWe found higher rates of CD4:CD8 ratio normalization compared with previous adult studies. Children who started ART at a younger age were more likely to recover a normal ratio. The current policy of universal treatment for all HIV-positive adults and children will enhance immunological normalization.

Indexed as

Infectious Disease Transmission, VerticalAdolescentAge FactorsAnti-HIV AgentsCD4-CD8 RatioChildCross-Sectional StudiesFemaleHIV InfectionsHumansLinear ModelsMaleRetrospective StudiesTreatment OutcomeUnited KingdomAnti-HIV AgentsCD4:CD8 ratioperinatally acquired HIV infection

Identifiers

PMID30084150
PMCPMC6221101
OpenAlexW2885721331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.