Evidence map›Paper›PMID 30084082›Full record

ArticleThe journal of physiological sciences : JPS2019

Epac1 deficiency inhibits basic fibroblast growth factor-mediated vascular smooth muscle cell migration.

Yuko Kato, Utako Yokoyama, Takayuki Fujita, Masanari Umemura, Tetsuo Kubota, Yoshihiro Ishikawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Regulation of bFGF-induced effects on rat aortic smooth muscle cells by βCurrent research in pharmacology and drug discovery · 2022
    Article
  5. Article
  6. EPAC in Vascular Smooth Muscle Cells.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yuko KatoCardiovascular Research Institute, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Utako YokoyamaCardiovascular Research Institute, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan. utako@yokohama-cu.ac.jp.ORCID http://orcid.org/0000-0003-1803-0155
Takayuki FujitaCardiovascular Research Institute, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Masanari UmemuraCardiovascular Research Institute, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Tetsuo KubotaDepartment of Immunopathology, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo, Japan.
Yoshihiro IshikawaCardiovascular Research Institute, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan. yishikaw@med.yokohama-cu.ac.jp.
Yokohama City University · JPTokyo Medical and Dental University · JP

Funding

Japan Agency for Medical Research and Development 66890007Japan Agency for Medical Research and Development 66891153Japan Society for the Promotion of Science JP15H05761Japan Society for the Promotion of Science JP16H05358Japan Society for the Promotion of Science JP17K08976Japan Society for the Promotion of Science JP17K19403Japan Society for the Promotion of Science JPH1605300Kitsuen Research Foundation 71890005
6 · The paper itself

Abstract

Vascular smooth muscle cell (VSMC) migration and the subsequent intimal thickening play roles in vascular restenosis. We previously reported that an exchange protein activated by cAMP 1 (Epac1) promotes platelet-derived growth factor (PDGF)-induced VSMC migration and intimal thickening. Because basic fibroblast growth factor (bFGF) also plays a pivotal role in restenosis, we examined whether Epac1 was involved in bFGF-mediated VSMC migration. bFGF-induced lamellipodia formation and migration were significantly decreased in VSMCs obtained from Epac1

Indexed as

AnimalsCell MovementCells, CulturedCoronary RestenosisFibroblast Growth FactorsGlycogen Synthase Kinase 3 betaGuanine Nucleotide Exchange FactorsMiceMuscle, Smooth, VascularMyocytes, Smooth MusclePhosphorylationProto-Oncogene Proteins c-aktSignal TransductionEpac protein, mouseFibroblast Growth FactorsGlycogen Synthase Kinase 3 betaGuanine Nucleotide Exchange FactorsProto-Oncogene Proteins c-aktBasic fibroblast growth factorExchange protein activated by cAMP 1Intimal thickeningMigrationVascular smooth muscle cells

Identifiers

PMID30084082
PMCPMC11117070
OpenAlexW2885813434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.