Evidence map›Paper›PMID 30084011›Full record

ArticleAnnals of hematology2018

Histiocytic cell neoplasms involving the bone marrow: summary of the workshop cases submitted to the 18th Meeting of the European Association for Haematopathology (EAHP) organized by the European Bone Marrow Working Group, Basel 2016.

Alexandar Tzankov, Markus Kremer, Roos Leguit, Attilio Orazi, Jon van der Walt, Umberto Gianelli, Konnie M Hebeda

Open access · hybridAbstract read
In one paragraph

Article in Annals of hematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Haematologica · 2022
    Article
  9. Article
  10. Article
  11. Potential role ofFrontiers in pediatrics · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The Spectrum of Aggressive Mastocytosis: A Workshop Report and Literature Review.Pathobiology : journal of immunopathology, molecular and cellular biology · 2020
    Review
  17. Review
  18. Article
  19. Article
  20. Red Blood Cells in Health and Disease.Journal of microscopy and ultrastructure
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 6 countries.

Alexandar TzankovInstitute of Pathology, University of Basel, Hospital, Schönbeinstrasse 40, 4055, Basel, Switzerland.
Markus KremerPathology, Städtisches Klinikum München, Sanatoriumsplatz 2, 81545, Munich, Germany.
Roos LeguitDepartment of Pathology, University Medical Center Utrecht, H04-312, POB 85500, 3508 GA, Utrecht, Netherlands.
Attilio OraziDivision of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 525 E, 68th Street, New York, NY, 10021, USA.
Jon van der WaltDepartment of Histopathology, Guy's and St Thomas' Hospitals, Westminster Bridge Road, London, SE1 7EH, UK.
Umberto GianelliPathology Unit, Department of Pathophysiology and Transplantation, University of Milan and Fondazione IRCCS, Ca' Granda - Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy.
Konnie M HebedaDepartment of Pathology 824, Radboud University Medical Center, POB 9101, 6500 HB, Nijmegen, The Netherlands. konnie.hebeda@radboudumc.nl.
Cornell University · USMünchen Klinik · DERadboud University Medical Center · NLSt Thomas' Hospital · GBUniversity Medical Center Utrecht · NLUniversity of Basel · CHUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bone marrow is a preferential site for both reactive and neoplastic histiocytic proliferations. The differential diagnosis ranges from reactive histiocyte hyperplasia in systemic infections, vaccinations, storage diseases, post myeloablative therapy, due to increased cell turnover, and in hemophagocytic lymphohistiocytosis, through extranodal Rosai-Dorfman disease to neoplasms derived from histiocytes, including histiocytic sarcomas (HS), Langerhans cell histiocytoses (LCH), Erdheim-Chester disease (ECD), and disseminated juvenile xanthogranuloma (JXG). One of the most important recent developments in understanding the biology of histiocytic neoplasms and in contributing to diagnosis was the detection of recurrent mutations of genes of the Ras/Raf/MEK/ERK signaling pathway, in particular the BRAF

Indexed as

Bone Marrow NeoplasmsHematologyHistiocytosisSocieties, MedicalAmino Acid SubstitutionCongresses as TopicEuropeHumansMAP Kinase Signaling SystemMutation, MissenseNeoplasm ProteinsNeoplasm ProteinsBone marrow biopsyEAHP workshopErdheim-Chester diseaseHistiocytic sarcomaMutationMyeloid neoplasm

Identifiers

PMID30084011
PMCPMC6182749
OpenAlexW2886899349

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.