Trial reportJapanese journal of ophthalmology2018
Effect of spectacle lenses designed to reduce relative peripheral hyperopia on myopia progression in Japanese children: a 2-year multicenter randomized controlled trial.
Trial report in Japanese journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 48 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Ophthalmic Lenses for Myopia Management
Efficacy and Safety of New Defocus Spectacle Lens in Preventing Progression of Myopia Compared With the Conventional Single-vision Spectacle Lens: a Randomized Controlled Trial Among Chinese Children
Who cites it
48 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Efficacy of spectacle lenses for myopia control: a meta-analysis of randomised controlled trials.The British journal of ophthalmology · 2026Pooled it
- Efficacy of interventions for myopia control in children: A systematic review with network meta-analyses.Acta ophthalmologica · 2025Pooled it
- Efficacy of spectacle lenses specifically designed for myopia control: systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Pooled it
- Myopia Control With Multifocal Lens in School-Aged Children: A Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Control of myopia using diffusion optics spectacle lenses: 12-month results of a randomised controlled, efficacy and safety study (CYPRESS).The British journal of ophthalmology · 2023Trial
- Spectacle lenses for control of myopia progression in children.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Review
- Low-Dose Atropine for Pediatric Myopia: First-Year Progression as a Risk-Stratification and Management Signal.Ophthalmology science · 2026Article
- Effect of Three Types of Specially-Designed Myopia Control Spectacle Lenses on Astigmatism: A Two-Year Result.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Comparative Effectiveness of Three Myopia Control Lenses: A Multicenter, Real-World Study of 5182 Adolescents and Children in Chongqing, China.Translational vision science & technology · 2026Article
- Myopia Management Consensus Statement in South Korean Children 2025 by the Korean Myopia Society for the Korean Association for Pediatric Ophthalmology and Strabismus.Korean journal of ophthalmology : KJO · 2026Review
- One-Year Efficacy and Tolerance of Myofix Defocus Spectacles for Control of Myopia Progression.Ophthalmology and therapy · 2026Article
- IMI-Interventions for Controlling Myopia Onset and Progression 2025.Investigative ophthalmology & visual science · 2025Review
- How Have Animal Models Increased our Understanding of Human Myopia?Investigative ophthalmology & visual science · 2025Review
- Axial elongation among Hong Kong myopic children and adolescents wearing single vision spectacles from a clinical setting.Scientific reports · 2025Article
- The Peripheral Defocus Designed Spectacle Lenses Might Increase Astigmatism in Myopic Children.Translational vision science & technology · 2025Article
- Reliability and validity of pre- and post-operative health-related quality of life in strabismus patients using the Japanese version of the adult strabismus questionnaire (AS-20).Japanese journal of ophthalmology · 2025Article
- Efficacy of Asymmetric Myopic Peripheral Defocus Lenses in Spanish Children: 24-Month Randomized Clinical Trial Results.Children (Basel, Switzerland) · 2025Article
- Myopia control efficacy of peripheral defocus modifying spectacle lenses in children and adolescents: a Meta-analysis.International journal of ophthalmology · 2025Article
- Myopia in Children: Epidemiology, Genetics, and Emerging Therapies for Treatment and Prevention.Children (Basel, Switzerland) · 2024Review
- Myopia Control: Are We Ready for an Evidence Based Approach?Ophthalmology and therapy · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNovel spectacle lenses (MyoVision, Carl Zeiss) designed to reduce relative peripheral hyperopia have been developed and reported to be effective for preventing myopia progression in a subgroup of Chinese children. In this study we examined the efficacy of MyoVision lenses in Japanese children. STUDY
designThis was a multicenter prospective randomized double-blind placebo-controlled trial.
methodWe enrolled 207 participants (aged 6-12 years) with spherical equivalent refractions (SERs) ranging from -1.5 to -4.5 diopters (D) and with at least 1 myopic parent. The participants were randomized to receive either single vision lenses (SVLs) or MyoVision lenses and were followed up every 6 months for 2 years. The primary outcome was myopia progression evaluated by cycloplegic autorefraction, and the secondary outcome was elongation of axial length.
resultsA total of 203 children (98.1%) completed the follow-up. The mean adjusted change in SER was -1.43 ± 0.10 D in the MyoVision group, which was not significantly different from that of the control group wearing SVLs (-1.39 ± 0.07 D) at the 24-month visit (P = .65). The adjusted axial length elongation was 0.73 ± 0.04 mm in the MyoVision group, which was not significantly different from that in the control group wearing SVLs (0.69 ± 0.03 mm) at the 24-month visit (P = .28).
conclusionThe results of this clinical trial could not verify the therapeutic effect of MyoVision for slowing down myopia progression in Japanese children. Additional studies are needed to design lenses that can reduce peripheral hyperopic defocus individually and to examine the effectiveness of these lenses in preventing myopia progression.
Indexed as
Identifiers
30083910What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.