Evidence map›Paper›PMID 30083792›Full record

ArticleObesity surgery2018

Thromboelastography Values Remain Hypercoagulative 6 Months After Obesity Surgery: a Pilot Study.

Mari Tuovila, Tiina Erkinaro, Vesa Koivukangas, Eeva-Riitta Savolainen, Päivi Laurila, Pasi Ohtonen, Tero Ala-Kokko

Abstract read
PubMed Publisher
In one paragraph

Article in Obesity surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Obesity is associated with postinjury hypercoagulability.The journal of trauma and acute care surgery · 2019
    Article
  6. Prospective assessment of fibrinolysis in morbid obesity: tissue plasminogen activator resistance improves after bariatric surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mari TuovilaDepartment of Anesthesia, Division of Intensive Care, Oulu University Hospital, Medical Research Center Oulu, Research Group of Surgery, Anaesthesiology and Intensive Care, Medical Faculty, University of Oulu, PO BOX 21, FI-90029, Oulu, Finland. mari.tuovila@ppshp.fi.ORCID http://orcid.org/0000-0002-0025-0865
Tiina ErkinaroDepartment of Anesthesia, Division of Intensive Care, Oulu University Hospital, Medical Research Center Oulu, Research Group of Surgery, Anaesthesiology and Intensive Care, Medical Faculty, University of Oulu, PO BOX 21, FI-90029, Oulu, Finland.
Vesa KoivukangasDivision of Operative Care, Oulu University Hospital and Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Eeva-Riitta SavolainenNordlab Oulu Hematology Laboratory, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Päivi LaurilaDepartment of Anesthesia, Division of Intensive Care, Oulu University Hospital, Medical Research Center Oulu, Research Group of Surgery, Anaesthesiology and Intensive Care, Medical Faculty, University of Oulu, PO BOX 21, FI-90029, Oulu, Finland.
Pasi OhtonenDivision of Operative Care, Oulu University Hospital and Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Tero Ala-KokkoDepartment of Anesthesia, Division of Intensive Care, Oulu University Hospital, Medical Research Center Oulu, Research Group of Surgery, Anaesthesiology and Intensive Care, Medical Faculty, University of Oulu, PO BOX 21, FI-90029, Oulu, Finland.
Oulu University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeObesity causes a prothrombotic state and is known as a predisposing factor for thromboembolic events. In this pilot study, we assessed the impact of surgery for obesity and the subsequent weight loss on blood coagulation using traditional coagulation tests and thromboelastography (TEG). MATERIAL AND

methodsWe studied blood samples from 18 patients receiving bariatric surgery. Besides traditional blood coagulation tests and high-sensitivity C-reactive protein (hsCRP) as a marker of inflammation, the TEG parameters reaction time (R), kinetics time (K), angle (α), maximum amplitude (MA), clot strength (G), and lysis percent at 60 min (LY60) were determined preoperatively and on the first postoperative day and 6 months after surgery.

resultsAltogether, 54 samples were analyzed. The median MA (71.3 mm), G (12,403.3 d/sc), and hsCRP (3.5 mg/l) were elevated preoperatively. The median hsCRP further increased on the first day postoperatively, but declined to the normal range 6 months after surgery, while MA and G remained elevated. In traditional coagulation tests, there was an increase in median fibrinogen and D-dimer postoperatively. D-dimer normalized (0.4 mg/l) during the study period, while the fibrinogen level (4.1 g/l) remained above the upper limit of normal.

conclusionsMeasured by TEG, patients receiving bariatric surgery have hemostatic abnormalities indicating hypercoagulation at the 6-month follow-up visit, suggesting an elevated risk for thromboembolic events for at least 6 months after surgery.

Indexed as

AdultBariatric SurgeryBlood CoagulationBlood Coagulation TestsFemaleFibrin Fibrinogen Degradation ProductsFibrinogenFollow-Up StudiesHumansMaleMiddle AgedObesity, MorbidPilot ProjectsPostoperative ComplicationsThrombelastographyThrombophiliaFibrin Fibrinogen Degradation Productsfibrin fragment DFibrinogenMorbid/surgeryObesityTEGVenous thromboembolism/blood

Identifiers

PMID30083792
OpenAlexW2887808234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.