Evidence map›Paper›PMID 30083621›Full record

ArticleJournal of preventive medicine and hygiene2018

Hospital discharge in patients at risk of surgical site infection: antimicrobial stewardship at Ferrara University Hospital, Italy.

P Antonioli, A Formaglio, D Gamberoni, L Bertoni, P Perrone, A Stefanati, M Libanore, R Cultrera, G Gabutti

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of preventive medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Antibiotic Overuse and Stewardship at Hospital Discharge: The Reducing Overuse of Antibiotics at Discharge Home Framework.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

P AntonioliDepartment of Hospital Hygiene & Healthcare Associated Infection Risk Management, Coordination of Clinical Health Promotion Activities, Hospital Health Medical Management, Ferrara University Hospital, Ferrara, Italy.
A FormaglioPostgraduate School of Hygiene and Preventive Medicine, University of Ferrara, Italy.
D GamberoniPostgraduate School of Hygiene and Preventive Medicine, University of Ferrara, Italy.
L BertoniPostgraduate School of Hygiene and Preventive Medicine, University of Ferrara, Italy.
P PerronePostgraduate School of Hygiene and Preventive Medicine, University of Ferrara, Italy.
A StefanatiSection of Public Health Medicine, Department of Medical Sciences, University of Ferrara, Italy.
M LibanoreHospital Infectious Diseases Clinic, Ferrara University Hospital, Ferrara, Italy.
R CultreraUniversity Infectious Diseases Clinic, Ferrara University Hospital, Ferrara, Italy.
G GabuttiSection of Public Health Medicine, Department of Medical Sciences, University of Ferrara, Italy.
University of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe appropriate use of antibiotics is a global priority in order to avoid antibiotic resistance. Up to 50% of antibiotics usage in hospital is inappropriate (e.g. prolonged surgical prophylaxis, "defensive medicine" approach). In 2015, at the Ferrara University Hospital, an antimicrobial stewardship intervention to reduce antimicrobial prescription at the time of hospital discharge in patients at risk of surgical site infection was implemented. This programme included: update meetings for health professionals, focused meetings for critical wards, reviews of some surgical prophylaxis protocols, recommendations to reduce broad-spectrum antimicrobials use, and planning of an audit. The purpose of this study has been to evaluate the effect of this antimicrobial stewardship programme.

methodsTo evaluate the effect of this intervention, a study has been carried out including inpatients in surveillance for surgical site infection who had surgery during the last quarter of 2014 (pre-intervention group; 461 patients) and of 2015 (post-intervention group; 532 patients).

resultsThe proportion of patients with prescription of at least one antimicrobial at discharge decreased from 33% to 24.4% (p = 0.002). The most prescribed categories of antimicrobials in both groups were the combination of penicillins with beta-lactamase inhibitors (with prescription rate reduced from 21.9% to 18%; p = 0.13) and fluoroquinolones (from 8.2% to 3.2%; p < 0.001).

conclusionsThis statistically significant reduction in antimicrobial prescription after the intervention was registered without a change in surgical site infections rate (from 3.5% to 3.2%; p = 0.08). Therefore, this intervention was effective in reducing the antimicrobial prescription at discharge, without affecting patients' safety.

Indexed as

Antimicrobial StewardshipDrug Resistance, MicrobialHospitals, UniversityPatient DischargeAdultAgedAged, 80 and overAnti-Bacterial AgentsFemaleHumansItalyMaleMiddle AgedPopulation SurveillanceRegistriesSurgical Wound InfectionAnti-Bacterial AgentsAntimicrobial stewardshipHospital dischargeSurgical patientsSurgical site infections

Identifiers

PMID30083621
PMCPMC6069401
OpenAlexW2891294137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.