Evidence map›Paper›PMID 30083611›Full record

ReviewScience advances2018

Accelerating a paradigm shift: The Common Fund Single Cell Analysis Program.

Ananda L Roy, Richard Conroy, Jessica Smith, Yong Yao, Andrea C Beckel-Mitchener, James M Anderson, Elizabeth L Wilder

Abstract readReview
In one paragraph

Review in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. SenNet Portal: Build, Optimization and Usage.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. CaMKIIα-Positive Interneurons Identified via a microRNA-Based Viral Gene Targeting Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ananda L RoyOffice of Strategic Coordination, National Institutes of Health (NIH), 6001 Executive Boulevard, Bethesda, MD 20892, USA.ORCID 0000-0002-0686-5748
Richard ConroyOffice of Strategic Coordination, National Institutes of Health (NIH), 6001 Executive Boulevard, Bethesda, MD 20892, USA.ORCID 0000-0002-8896-6090
Jessica SmithOffice of Strategic Coordination, National Institutes of Health (NIH), 6001 Executive Boulevard, Bethesda, MD 20892, USA.ORCID 0000-0002-4381-0279
Yong YaoDivision of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA.
Andrea C Beckel-MitchenerDivision of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA.
James M AndersonDivision of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, NIH, Bethesda, MD 20892, USA.ORCID 0000-0003-2765-7996
Elizabeth L WilderOffice of Strategic Coordination, National Institutes of Health (NIH), 6001 Executive Boulevard, Bethesda, MD 20892, USA.

Funding

Novel approaches to study dynamic coupling of the tight junction barrier to the actin cytoskeletonZIAHL006207 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ANDERSON, JAMES · 2016 to 2016
$461k
6 · The paper itself

Abstract

It has become exceedingly important to understand the precise molecular profiles of the nearly 40 trillion cells in an adult human because of their role in determining health, disease, and therapeutic outcome. The National Institutes of Health (NIH) Common Fund-supported Single Cell Analysis Program (SCAP) was designed to address this challenge. In this review, we outline the original program goals and provide a perspective on the impact of the program as a catalyst for exploration of heterogeneity of human tissues at the cellular level. We believe that the technological advances in single-cell RNA sequencing and multiplexed imaging combined with computational methods made by this program will undoubtedly have an impact on broad and robust applications of single-cell analyses in both health and disease research.

Indexed as

Computational BiologyHigh-Throughput Nucleotide SequencingHumansNational Institutes of Health (U.S.)Sequence Analysis, RNASingle-Cell AnalysisUnited States

Identifiers

PMID30083611
PMCPMC6070315

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.