ArticleCanadian journal of kidney health and disease2018
Is the Kidney Donor Risk Index a Useful Tool in Non-US Patients?
Article in Canadian journal of kidney health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Machine learning models in predicting graft survival in kidney transplantation: meta-analysis.BJS open · 2023Pooled it
- Using Information Available at the Time of Donor Offer to Predict Kidney Transplant Survival Outcomes: A Systematic Review of Prediction Models.Transplant international : official journal of the European Society for Organ Transplantation · 2022Pooled it
- An external validation of the Kidney Donor Risk Index in the UK transplant population in the presence of semi-competing events.Diagnostic and prognostic research · 2023Article
- A pre-transplantation risk assessment tool for graft survival in Dutch pediatric kidney recipients.Clinical kidney journal · 2023Article
- Kidney Donor Profile Index and allograft outcomes: interactive effects of estimated post-transplant survival score and ischaemic time.Clinical kidney journal · 2023Article
- Common predictors of adverse outcomes in adult deceased donor kidney transplant recipients with varying sensitization.American journal of clinical and experimental urology · 2023Article
- Predicting Kidney Graft Survival Using Machine Learning Methods: Prediction Model Development and Feature Significance Analysis Study.Journal of medical Internet research · 2021Article
- Kidney Transplantation in Times of Covid-19: Decision Analysis in the Canadian Context.Canadian journal of kidney health and disease · 2021Article
- Predicting Clinical Outcome in Expanded Criteria Donor Kidney Transplantation: A Retrospective Cohort Study.Canadian journal of kidney health and disease · 2020Article
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8 authors.
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Abstract
backgroundDeceased donor kidney allocation in the United States is guided by the Kidney Donor Risk Index (KDRI). The generalizability of the KDRI beyond the United States has not been widely studied.
objectiveTo assess the generalizability of the KDRI in a cohort of non-US (Canadian) deceased donor kidney transplant recipients.
designPopulation-based retrospective cohort study.
settingOntario, Canada. PATIENTS: Recipients of deceased donor kidneys from January 1, 2005, to March 31, 2011.
methodsUsing administrative data, we analyzed a cohort of deceased donor kidney recipients in Ontario, Canada. The Kaplan-Meier method and Cox proportional hazards models were used to assess the relationship between KDRI and the outcomes of graft loss and death. KDRI was modeled continuously and categorically. The ability of models with KDRI to predict recipient outcomes beyond donor age was also explored. Model discrimination was assessed using
resultsA total of 1299 consecutive deceased donor kidney transplant recipients were included. The median follow-up was 5.5 years. Mean donor age increased from 27 to 64 years across ascending KDRI quintiles. The adjusted relative hazards (95% confidence interval) for total graft loss from Q2 to Q5 (referent = Q1) were 1.27 (0.89-1.80), 1.58 (1.13-2.22), 1.43 (1.01-2.02), and 2.15 (1.54-2.99), respectively. Increased relative hazards across KDRI quintiles were also observed for death-censored graft loss, but not death with graft function. All-cause mortality was increased for the highest KDRI quintile only. In this cohort, a model with KDRI performed better than a model with donor age alone ( LIMITATIONS: Large health care databases may have precluded the complete capture of covariate data.
conclusionsIn conclusion, the KDRI is generalizable to Canadian patients in Ontario and may help inform risk assessment beyond donor age. The performance of KDRI in other non-US settings, and the need for additional model refinement, warrants further study.
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