ArticleUnited European gastroenterology journal2018
Malignancy and Meckel's diverticulum: A systematic literature review and 14-year experience at a tertiary referral center.
Article in United European gastroenterology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 41 citations in OpenAlex.
- Acute lower gastrointestinal bleeding from Meckel's diverticulum in a young adult: a case report on surgical management.International journal of surgery case reports · 2026Article
- Article
- Long-term disease-free survival following preoperative diagnosis and laparoscopic radical resection for Meckel's diverticulum adenocarcinoma: A case report.World journal of gastrointestinal surgery · 2026Article
- Neuroendocrine tumor arising in Meckel's diverticulum presenting with bowel obstruction.Journal of surgical case reports · 2026Article
- Article
- Acute abdomen due to Meckel's diverticulitis with synchronous inflammatory myofibroblastic tumor in the terminal ileum: A case report.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2024Article
- An Extremely Rare Presentation of Mucinous Adenocarcinoma Originating From Meckel Diverticulum Masquerading in a Young Woman With Crohn's Disease.ACG case reports journal · 2024Article
- Perforation of Meckel's diverticulum by an unusual foreign body: A case report and a review of literature.Clinical case reports · 2024Article
- Simultaneous resection of a neuroendocrine tumor in an incidental Meckel's diverticulum with transabdominal preperitoneal hernial repair: a case report.Surgical case reports · 2024Article
- Should an Incidental Meckel Diverticulum Be Resected? A Systematic Review.Clinical and experimental gastroenterology · 2024Review
- An unusual form of incisional hernia: A case report of Littre's hernia.International journal of surgery case reports · 2023Article
- Intestinal adenocarcinoma originating from an undiagnosed Meckel's diverticulum.Journal of surgical case reports · 2022Article
- Metachronous Krukenberg tumor from adenocarcinoma in a Meckel's diverticulum: a case report.Journal of surgical case reports · 2021Article
- The Many Faces of Meckel's Diverticulum: Update on Management in Incidental and Symptomatic Patients.Current gastroenterology reports · 2020Review
- "-Omas" presenting as "-itis": acute inflammatory presentations of common gastrointestinal neoplasms.Emergency radiology · 2019Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMeckel's diverticulum is present in about 2% of the population. The literature reports 3.2% incidence of tumors within Meckel's diverticulum; the tumors are predominantly benign. OBJECTIVE AND
methodsThe purpose of this study was to evaluate malignant tumors in Meckel's diverticulum through systematic review of the literature and review of electronic medical records including pathology reports over 14 years at the Mayo Clinic, Rochester, USA.
resultsA literature review over the last 10 years identified 37 citations with 402 patients (median age: 58 years; 68.9% males). The predominant malignancy reported was neuroendocrine tumor 84.6%, followed by gastrointestinal stromal tumor 8.2%, and adenocarcinoma 6%. At the time of diagnosis, 29.5% of patients had metastases. In the Mayo Clinic electronic medical records review, there were 19 patients (5.1% of them surgically removed Meckel's diverticulum) who had a malignancy associated with Meckel's diverticulum: 63.2% neuroendocrine tumor, 10.5% gastrointestinal stromal tumor, 5.3% adenocarcinoma, 5.3% pancreatic epithelial neoplasia, and 15.8% metastases from secondary location. Median size of the malignancy was 7 mm, and 17/19 malignancies were coincidental findings. Most neuroendocrine tumors infiltrated the submucosa, while gastrointestinal stromal tumor and adenocarcinoma invaded the serosa. At the time of diagnosis, 33.3% of patients had metastases.
conclusionAbout 5% of Meckel's diverticulums resected were associated with malignant tumors, most commonly neuroendocrine tumor, and a significant portion of Meckel's diverticulum malignancy was metastatic at the time of discovery.
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