ArticleDiabetology & metabolic syndrome2018
Normoalbuminuric kidney impairment in patients with T1DM: insights from annals initiative.
Article in Diabetology & metabolic syndrome, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Inflammation and Adverse Outcomes in Patients With Acute Ischemic Stroke With and Without Chronic Kidney Disease.Journal of the American Heart Association · 2024Article
- Re-understanding and focusing on normoalbuminuric diabetic kidney disease.Frontiers in endocrinology · 2022Review
- Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency.European journal of medical research · 2021Review
- Low eGFR Is a Strong Predictor of Worse Outcome in Hospitalized COVID-19 Patients.Journal of clinical medicine · 2021Article
- Review
- Urine Metabolomics Analysis in Patients With Normoalbuminuric Diabetic Kidney Disease.Frontiers in physiology · 2020Article
- A review of urinary angiotensin converting enzyme 2 in diabetes and diabetic nephropathy.Biochemia medica · 2019Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe described, in a large sample of patients with type 1 diabetes mellitus (T1DM) and GFR ≤ 60 mL/min/1.73 m
methodsClinical data of 1395 patients with T1DM were extracted from electronic medical records.
resultsAlbuminuria was detected in 676 (48.5%) patients, with the remaining 719 (51.5%) patients having normoalbuminuric renal impairment. Those with albuminuria showed an evident worse cardiovascular risk profile as compared to patients with normoalbuminuria. A subgroup of 582 patients was followed up over a 4-year period. One hundred and twenty five patients (21.5%) showed a loss of eGFR > 30%. The proportion of patients reaching the renal outcome was significantly higher among those with baseline albuminuria as compared to patients with normoalbuminuria (P < 0.0001). At the multivariate logistic analysis microalbuminuria, macroalbuminuria and proliferative retinopathy were the only parameters independently associated to eGFR reduction.
conclusionsThe proportion of T1DM patients with normoalbuminuria renal impairment is high (about 50%). These patients have a slower eGFR decline as compared to that observed in patients with albuminuria renal impairment.
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