ArticleThyroid research2018
A rare malignant thyroid carcinosarcoma with aggressive behavior and DICER1 gene mutation: a case report with literature review.
Article in Thyroid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Glomangiosarcoma-like Anaplastic Transformation in Papillary Thyroid Carcinoma: A Novel Form of Heterologous Differentiation and a Systematic Review of Heterologous Element Prevalence.Endocrine pathology · 2023Pooled it
- Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group.Familial cancer · 2021Guideline
- Thyroblastoma in Pregnancy: Expanding the Cytomorphological Spectrum of a Novel DICER1 -Associated Entity, a Case Report and Literature Review.Diagnostic cytopathology · 2025Review
- Decisive role of surgery on improving overall survival outcomes of primary thyroid sarcoma: the first long-term cohort study.Endocrine · 2025Article
- Case Report: A rare case of chest wall thyroid carcinosarcoma.Frontiers in oncology · 2025Article
- Diagnosis and treatment of thyroblastoma: a case report and review of literature.Frontiers in oncology · 2025Article
- Expanding Our Knowledge ofCancers · 2024Review
- Thyroid carcinosarcoma masquerading as a paraesophageal abscess in a Cane Corso dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2023Article
- Primary Thyroid Neoplasm with Fetal Morphology Associated withThyroid : official journal of the American Thyroid Association · 2022Article
- Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.Endocrinology and metabolism (Seoul, Korea) · 2022Review
- Clinical outcomes of thyroid tumours with concurrent epithelial and mesenchymal components in 14 dogs (2006-2020).Veterinary medicine and science · 2022Article
- Phenotypic similarities within the morphologic spectrum of DICER1-associated sarcomas and pleuropulmonary blastoma: Histopathologic features guide diagnosis in the LMIC setting.Pediatric blood & cancer · 2022Article
- Overview of the 2022 WHO Classification of Familial Endocrine Tumor Syndromes.Endocrine pathology · 2022Review
- High Prevalence of DICER1 Mutations and Low Frequency of Gene Fusions in Pediatric Follicular-Patterned Tumors of the Thyroid.Endocrine pathology · 2021Article
- Inherited Follicular Epithelial-Derived Thyroid Carcinomas: From Molecular Biology to Histological Correlates.Endocrine pathology · 2021Review
- Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations-is the term "thyroblastoma" more appropriate?Virchows Archiv : an international journal of pathology · 2020Article
- Comprehensive guidance on the diagnosis and management of primary mesenchymal tumours of the thyroid gland.The Lancet. Oncology · 2020Review
- Poorly differentiated thyroid carcinoma of childhood and adolescence: a distinct entity characterized by DICER1 mutations.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Expanding the spectrum of dicer1-associated sarcomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- The Histological Spectrum of DICER1-Associated Neoplasms.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology SocietyReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalignant biphasic tumor also known as carcinosarcoma is an uncommon neoplasm that is composed of both malignant epithelial and mesenchymal components. Most reported cases of carcinosarcoma affect the female genital tract; however, other sites including head and neck, lung, and breast have been described. Carcinosarcoma of the thyroid is an extremely rare and aggressive malignancy with an ominous clinical course similar to anaplastic carcinoma. CASE PRESENTATION: We report a case of a 45-year-old female who was found to have a biphasic thyroid carcinosarcoma. Her clinical course declined significantly shortly after she underwent a total thyroidectomy and she developed distant metastases to the lungs. Histopathological features of the primary and metastatic tumor were identical. The tumor is composed of an intimately intermixed epithelial component of poorly differentiated follicular thyroid carcinoma and a spindle cell sarcoma with rhabdomyosarcoma differentiation. Molecular analysis using a next-generation sequencing based assay revealed a
conclusionTo our knowledge, the E1705K point mutation within the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.