ArticleIranian endodontic journal2018
Cytotoxicity of Endodontic Irrigants on Human Periodontal Ligament Cells.
Article in Iranian endodontic journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Tissue-friendly dentin treatments as a potential element in revascularization protocol (ex-vivo study).BMC oral health · 2025Article
- "Comparative evaluation of cytotoxicity of three herbal endodontic irrigants at three intervals of time" - AnJournal of conservative dentistry and endodontics · 2024Article
- Exploring Periostracum as an Alternative Root Canal Irrigant: Insights From Zebrafish Embryo Experiments.Cureus · 2024Article
- Antifungal and genotoxic effects of Thymus serpyllum as a root canal irrigant.Clinical and experimental dental research · 2024Article
- Effect of 5% Carbohydrate Derived-Fulvic Acid on Smear Layer Removal and Root Dentin Microhardness - An In Vitro study.European endodontic journal · 2022Article
- Comparative effects of Er:YAG laser, and EDTA, MTAD, and QMix irrigants on adhesion of stem cells from the apical papilla to dentin: A scanning electron microscopic study.Journal of clinical and experimental dentistry · 2022Article
- Antimicrobial and cytotoxic activity of electrosprayed chitosan nanoparticles against endodontic pathogens and Balb/c 3T3 fibroblast cells.Scientific reports · 2021Article
- Final Endodontic Irrigation with 2% Peracetic Acid: Antimicrobial Activity and Cytotoxicity.European journal of dentistry · 2021Article
- Dehydrobufotenin extracted from the Amazonian toadThe journal of venomous animals and toxins including tropical diseases · 2021Article
- A small molecule II-6s inhibitsJournal of oral microbiology · 2021Article
- An Overview on a Promising Root Canal Irrigation Solution: QMix.Iranian endodontic journal · 2021Article
- The Effects of Sodium Hypochlorite on Organic Matters: Influences of Concentration, Renewal Frequency and Contact Area.Iranian endodontic journal · 2020Article
- Photodynamic Therapy With Resveratrol and an Nd:YAG Laser forIn vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRoot canal irrigation has an extremely important role in the success of endodontic treatment. During endodontic treatment, the irrigants will be in contact with pulpal and periapical tissues. The purpose of this study was to clarify the potential toxicological implications of NaOCl, EDTA, MTAD, CHX and QMix on periapical and periodontal tissues. METHODS AND MATERIALS: Cytotoxicity of solutions was evaluated on cultured human periodontal ligament (hPDL) that were carefully removed from the middle third of premolar roots. Cytotoxicity of the materials was assessed after 1, 5 and 15 min of exposure using the Mosmann's Tetrazolium Toxicity (MTT) assay. Optical density of the solution was read at 540-690 nm wavelength. The intensity of color generated correlated with the percentage of viable cells. Data were statistically analyzed using repeated measures ANOVA followed by Bonferroni test.
resultsThe mean percentage of viable cells in all experimental groups was significantly different from sterile saline groups at all time points (
conclusionMTAD had the lowest cytotoxicity compared to NaOCl, CHX, QMix and EDTA. These impacts have been time dependent. These irrigation fluids may cause unfavorable effects on vital tissues.
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