Evidence map›Paper›PMID 30083152›Full record

ArticleFrontiers in immunology2018

Interleukin-10 Producing Regulatory B Cells Transformed CD4

Mohd Tarique, Huma Naz, Santosh V Kurra, Chaman Saini, Raza Ali Naqvi, Reeta Rai, Mohd Suhail, Neena Khanna, Donthamshetty N Rao, Alpana Sharma

Abstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Leprosy.Nature reviews. Disease primers · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Mesenchymal stem cells and their microenvironment.Stem cell research & therapy · 2022
    Review
  19. Tafazzin deficiency in mouse mesenchymal stem cells promote reprogramming of activated B lymphocytes toward immunosuppressive phenotypes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohd TariqueDepartment of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Huma NazCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Santosh V KurraDepartment of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Chaman SainiDepartment of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Raza Ali NaqviDepartment of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Reeta RaiDepartment of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Mohd SuhailKing Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Neena KhannaDepartment of Dermatovenerology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Donthamshetty N RaoDepartment of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Alpana SharmaDepartment of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory B cells (Bregs) are known to exhibit their regulatory functions through interleukin-10 (IL-10) cytokine which suppress inflammation. There are only a few studies explaining the phenotype and functioning of these cells in contribution to host immunity in leprosy. Here, we evaluated the role of IL-10 producing Bregs in the pathogenesis of leprosy and assessed their immunoregulatory effects on Tregs and effector T cells. We found an increased frequency of Bregs and increased expression of their immune modulatory molecules (IL-10, FoxP3, and PDL-1) in leprosy patients. The potential immunoregulatory mechanism of Bregs was also investigated using MACS sorted Teff (CD4

Indexed as

FoxP3interleukin-10leprosyregulatory B cellsTeff cellsTregs

Identifiers

PMID30083152
PMCPMC6065098

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.