ReviewFrontiers in physiology2018
Limitation of Maximal Heart Rate in Hypoxia: Mechanisms and Clinical Importance.
Review in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of exercise on multiple health outcomes in children and adolescents with overweight or obesity: a meta-analysis of 176 randomized controlled trials and its implications for global obesity prevention.The international journal of behavioral nutrition and physical activity · 2026Pooled it
- Effects of exercise interventions in hypoxic environment on cardiovascular function and maximal power output in obese or overweight individuals: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Oxygen saturation and acute mountain sickness during repeated altitude exposures simulating high-altitude working schedules.Scientific reports · 2025Trial
- The Combined Effect of Multisensory Stimulation and Therapist Support on Physical and Mental Health of Older Adults Living in Nursing Homes: Pilot Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Low- and moderate-intensity aerobic exercise improves the physiological acclimatization of lowlanders on the Tibetan plateau.European journal of sport science · 2024Trial
- Helpful to Live Healthier? Intermittent Hypoxic/Ischemic Training Benefits Vascular Homeostasis and Lipid Metabolism with Activating SIRT1 Pathways in Overweight/Obese Individuals.Obesity facts · 2024Trial
- Trial
- Surgical masks and filtering facepiece class 2 respirators (FFP2) have no major physiological effects at rest and during moderate exercise at 3000-m altitude: a randomised controlled trial.Journal of travel medicine · 2023Trial
- Exercise Performance of Lowlanders with Chronic Obstructive Pulmonary Disease Acutely Exposed to 2048 m: A Randomized Cross-Over Trial.International journal of chronic obstructive pulmonary disease · 2023Trial
- Trial
- Cardiovascular Exercise Physiology Under Hypoxia, Microgravity, and Heat Stress: A Review with Public Health Implications.International journal of environmental research and public health · 2026Review
- A theoretical framework for predicting altitude effects on physical employment standard evaluation performance.Frontiers in physiology · 2026Article
- Hematological, inflammatory, and hypoxia-responsive adaptations to 18-day normobaric live high-train low training in elite rowers.Frontiers in physiology · 2026Article
- Normobaric Hypoxic Cardiac Rehabilitation: Comparative Effects of Training at 2000 m and 3000 m Simulated Altitude in Post-Myocardial Infarction Patients.Journal of functional morphology and kinesiology · 2025Article
- Lactate Thresholds and Performance in Young Cross-Country Skiers Before and After the Competitive Season: Insights from Laboratory Roller-Ski Tests in Normoxic and Hypoxic Conditions.Sports (Basel, Switzerland) · 2025Article
- Comparison of the Effects of Endurance Training Conducted in Conditions of Normoxia and Artificial Hypoxia in Patients After Myocardial Infarction.Journal of clinical medicine · 2025Article
- Changes and monitoring technology of human heart rate and blood oxygen saturation under high-altitude hypoxia.Frontiers in physiology · 2025Review
- Hypoxia matters: comparison of external and internal training load markers during an 8-week resistance training program in normoxia, normobaric hypoxia and hypobaric hypoxia.European journal of applied physiology · 2024Article
- Estimation of ventilatory thresholds during exercise using respiratory wearable sensors.NPJ digital medicine · 2024Article
- Independent, additive and interactive effects of acute normobaric hypoxia and cold on submaximal and maximal endurance exercise.European journal of applied physiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of exercise intervention in hypoxia has grown in popularity amongst patients, with encouraging results compared to similar intervention in normoxia. The prescription of exercise for patients largely rely on heart rate recordings (percentage of maximal heart rate (HR
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.