Evidence map›Paper›PMID 30083093›Full record

ArticleFrontiers in neural circuits2018

A Versatile Method for Viral Transfection of Calcium Indicators in the Neonatal Mouse Brain.

Cynthia X He, Erica D Arroyo, Daniel A Cantu, Anubhuti Goel, Carlos Portera-Cailliau

Abstract read
In one paragraph

Article in Frontiers in neural circuits, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Network state transitions during cortical development.Nature reviews. Neuroscience · 2024
    Review
  6. Article
  7. Article
  8. Loss of Depalmitoylation Disrupts Homeostatic Plasticity of AMPARs in a Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  9. Article
  10. Article
  11. Two-photon calcium imaging of neuronal activity.Nature reviews. Methods primers · 2022
    Article
  12. Article
  13. AnFrontiers in neural circuits · 2021
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cynthia X HeDepartment of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, United States.
Erica D ArroyoDepartment of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, United States.
Daniel A CantuDepartment of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, United States.
Anubhuti GoelDepartment of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, United States.
Carlos Portera-CailliauDepartment of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, United States.

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Imaging the origin of dendritic spine abnormalities in fragile X miceR01HD054453 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Carlos Portera-Cailliau · 2007 to 2026
$6.5M
Training Grant in Neurobehavioral GeneticsT32MH073526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, GESCHWIND, DANIEL H · 2006 to 2020
$2.4M
Training Program in Neural MicrocircuitsT32NS058280 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2007 to 2017
$2.4M
Linking defects in cortical network activity with altered sensory perception in Fragile X miceF30NS093719 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HE, CYNTHIA · 2015 to 2018
$151k
NICHD NIH HHS R01 HD054453NIGMS NIH HHS T32 GM008042NIMH NIH HHS T32 MH073526NINDS NIH HHS F30 NS093719NINDS NIH HHS T32 NS058280
6 · The paper itself

Abstract

The first three postnatal weeks in rodents are a time when sensory experience drives the maturation of brain circuits, an important process that is not yet well understood. Alterations in this critical period of experience-dependent circuit assembly and plasticity contribute to several neurodevelopmental disorders, such as autism, epilepsy, and schizophrenia. Therefore, techniques for recording network activity and tracing neuronal connectivity over this time period are necessary for delineating circuit refinement in typical development and how it deviates in disease. Calcium imaging with GCaMP6 and other genetically encoded indicators is rapidly becoming the preferred method for recording network activity at the single-synapse and single-cell level

Indexed as

Cerebral CortexNeuronsAnimalsAnimals, NewbornCalciumCalcium SignalingCalmodulinDependovirusGreen Fluorescent ProteinsMiceMicroscopy, Fluorescence, MultiphotonMyosin Light ChainsRecombinant ProteinsTransfectionCalciumCalmodulinGreen Fluorescent ProteinsMyosin Light ChainsRecombinant ProteinscortexdevelopmentGCaMPin vivoneuronal activityrAAVsparsificationtwo-photon

Identifiers

PMID30083093
PMCPMC6064716

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.