ArticleFood & nutrition research2018
Glutamine supplementation improves intestinal cell proliferation and stem cell differentiation in weanling mice.
Article in Food & nutrition research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review.International journal of molecular sciences · 2019Pooled it
- [Clinical effect of alanyl-glutamine-enriched nutritional support in the treatment of children with abdominal Henoch-Schönlein purpura].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Trial
- Establishing Murine Intestinal Organoids to Study Nutrient- and Tastant-Evoked Gut Signaling.Nutrients · 2026Article
- Article
- Diabetes-preventive molecular mechanisms of breast versus formula feeding: new insights into the impact of milk on stem cell Wnt signaling.Frontiers in nutrition · 2025Review
- Long-Term L-Glutamine Treatment Reduces Hemolysis without Ameliorating Hepatic Vaso-Occlusion and Liver Fibrosis in a Mouse Model of Sickle Cell Disease.Biomedicines · 2023Article
- Article
- The role of amino acid metabolism in inflammatory bowel disease and other inflammatory diseases.Frontiers in immunology · 2023Review
- Effect of glutamine use on the formation of intestinal neomucosa on peritoneal surface in rats.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Gut homeostasis, injury, and healing: New therapeutic targets.World journal of gastroenterology · 2022Review
- Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8Nature communications · 2022Article
- Nutritional stimulation by in-ovo feeding modulates cellular proliferation and differentiation in the small intestinal epithelium of chicks.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Glutamine, glutamate, and aspartate differently modulate energy homeostasis of small intestine under normal or low energy status in piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- CaFrontiers in pharmacology · 2022Article
- Article
- The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis.Nutrients · 2021Review
- Effects of Oral Glutamine Supplementation on Early Postnatal Muscle Morphology in Low and Normal Birth Weight Piglets.Animals : an open access journal from MDPI · 2020Article
- Exogenous L-arginine increases intestinal stem cell function through CD90+ stromal cells producing mTORC1-induced Wnt2b.Communications biology · 2020Article
- Plasticity of Paneth cells and their ability to regulate intestinal stem cells.Stem cell research & therapy · 2020Review
- Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome.World journal of gastroenterology · 2020Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntestinal stem cells can be differentiated into absorptive enterocytes and secretory cells, including Paneth cells, goblet cells, and enteroendocrine cells. Glutamine is a primary metabolic fuel of small intestinal enterocytes and is essential for the viability and growth of intestinal cells.
objectiveWhether glutamine supplementation affects the differentiation of intestinal stem cells is unknown.
designThree-week-old ICR (Institute of Cancer Research) male mice were divided randomly into two groups: 1) mice receiving a basal diet and normal drinking water and 2) mice receiving a basal diet and drinking water supplemented with glutamine. After 2 weeks, the mice were sacrificed to collect the ileum for analysis.
resultsThe study found that glutamine supplementation in weanling mice decreases the crypt depth in the ileum, leading to higher ratio of villus to crypt in the ileum, but promotes cell proliferation of intestinal cells and mRNA expression of Lgr5 (leucine-rich repeat-containing g-protein coupled receptor5) in the ileum. Glutamine has no effect on the number of Paneth cells and goblet cells, and the expression of markers for absorptive enterocytes, Paneth cells, goblet cells, and enteroendocrine cells.
conclusionThese findings reveal the beneficial effects of dietary glutamine supplementation to improve intestinal morphology in weanling mammals.
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