Evidence map›Paper›PMID 30083023›Full record

ArticleJournal of the American Statistical Association2018

Efficient Estimation for Semiparametric Structural Equation Models With Censored Data.

Kin Yau Wong, Donglin Zeng, D Y Lin

Abstract read
In one paragraph

Article in Journal of the American Statistical Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Causal inference in the diagnosis and prognosis of ovarian cancer: current state and future directions.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Pooled it
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kin Yau WongDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC 27599.
Donglin ZengDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC 27599.
D Y LinDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC 27599.

Funding

Statistical Methods for Cancer Clinical TrialsP01CA142538 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KOSOROK, MICHAEL R · 2010 to 2019
$21.3M
STATISTICAL METHODS IN CURRENT CANCER RESEARCHR01CA082659 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, DANYU · 2000 to 2016
$3.7M
Semiparametric Regression Analysis of Censored DataR01GM047845 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, DANYU · 1997 to 2018
$2.9M
NCI NIH HHS P01 CA142538NCI NIH HHS R01 CA082659NIGMS NIH HHS R01 GM047845
6 · The paper itself

Abstract

Structural equation modeling is commonly used to capture complex structures of relationships among multiple variables, both latent and observed. We propose a general class of structural equation models with a semiparametric component for potentially censored survival times. We consider nonparametric maximum likelihood estimation and devise a combined Expectation-Maximization and Newton-Raphson algorithm for its implementation. We establish conditions for model identifiability and prove the consistency, asymptotic normality, and semiparametric efficiency of the estimators. Finally, we demonstrate the satisfactory performance of the proposed methods through simulation studies and provide an application to a motivating cancer study that contains a variety of genomic variables. Supplementary materials for this article are available online.

Indexed as

Integrative analysisJoint modelingLatent variablesModel identifiabilityNonparametric maximum likelihood estimationSurvival analysis

Identifiers

PMID30083023
PMCPMC6075718

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.