ArticleScientific reports2018
Hydra Mesoglea Proteome Identifies Thrombospondin as a Conserved Component Active in Head Organizer Restriction.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Mutual inhibition model of pattern formation: The role of Wnt-Dickkopf interactions in driving Hydra body axis formation.PLoS computational biology · 2026Article
- Coral larval proteomics at onset of metamorphosis highlights innate immunity maturation in parallel to neuro-sensing and skeletal development.Frontiers in physiology · 2026Article
- Extracellular matrix remodeling supportsbioRxiv : the preprint server for biology · 2025Article
- Article
- Proteomic Diversity of the Sea AnemoneMarine drugs · 2025Article
- Thrombospondins: Conserved mediators and modulators of metazoan extracellular matrix.International journal of experimental pathology · 2024Review
- TheBiomedicines · 2024Article
- Epithelial wound healing in Clytia hemisphaerica provides insights into extracellular ATP signaling mechanisms and P2XR evolution.Scientific reports · 2023Article
- Wnt/β-catenin signaling induces axial elasticity patterns ofiScience · 2023Article
- siRNA-mediated gene knockdown via electroporation in hydrozoan jellyfish embryos.Scientific reports · 2022Article
- Cellular, Metabolic, and Developmental Dimensions of Whole-Body Regeneration inCold Spring Harbor perspectives in biology · 2021Review
- The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra.BMC biology · 2021Article
- The Aquatic InvertebrateFrontiers in cell and developmental biology · 2021Article
- Bacteria- and temperature-regulated peptides modulate β-catenin signaling inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Stem cell differentiation trajectories inScience (New York, N.Y.) · 2019Article
- Differential regulation of myc homologs by Wnt/β-Catenin signaling in the early metazoan Hydra.The FEBS journal · 2019Article
- Emergence of a Thrombospondin Superfamily at the Origin of Metazoans.Molecular biology and evolution · 2019Article
- An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra.Nature communications · 2019Article
- Molecular signature of an ancient organizer regulated by Wnt/β-catenin signalling during primary body axis patterning inCommunications biology · 2019Article
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
Abstract
Thrombospondins (TSPs) are multidomain glycoproteins with complex matricellular functions in tissue homeostasis and remodeling. We describe a novel role of TSP as a Wnt signaling target in the basal eumetazoan Hydra. Proteome analysis identified Hydra magnipapillata TSP (HmTSP) as a major component of the cnidarian mesoglea. In general, the domain organization of cnidarian TSPs is related to the pentameric TSPs of bilaterians, and in phylogenetic analyses cnidarian TSPs formed a separate clade of high sequence diversity. HmTSP expression in polyps was restricted to the hypostomal tip and tentacle bases that harbor Wnt-regulated organizer tissues. In the hypostome, HmTSP- and Wnt3-expressing cells were identical or in close vicinity to each other, and regions of ectopic tentacle formation induced by pharmacological β-Catenin activation (Alsterpaullone) corresponded to foci of HmTSP expression. Chromatin immunoprecipitation (ChIP) confirmed binding of Hydra TCF to conserved elements in the HmTSP promotor region. Accordingly, β-Catenin knockdown by siRNAs reduced normal HmTSP expression at the head organizer. In contrast, knockdown of HmTSP expression led to increased numbers of ectopic organizers in Alsterpaullone-treated animals, indicating a negative regulatory function. Our data suggest an unexpected role for HmTSP as a feedback inhibitor of Wnt signaling during Hydra body axis patterning and maintenance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.