ArticleOncogene2019
Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ.
Abstract read
In one paragraph
Article in Oncogene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
What it found
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Who cites it
48 citing papers in PubMed, 66 citations in OpenAlex.
- Amlodipine exerts inhibitory effects against glioma stem cells through degrading EGFR and down-regulating its downstream pro-survival pathways.Cell death discovery · 2025Article
- Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma.Journal of functional biomaterials · 2025Review
- Regulation of formin INF2 and its alteration in INF2-linked inherited disorders.Cellular and molecular life sciences : CMLS · 2024Review
- A highly sensitive reporter system to monitor endogenous YAP1/TAZ activity and its application in various human cells.Cancer science · 2024Article
- The Reappraisal of the Reappraisal-CRAC Channels Are Activated by L-Type CaFunction (Oxford, England) · 2024Article
- Construction of disulfidptosis-based immune response prediction model with artificial intelligence and validation of the pivotal grouping oncogene c-MET in regulating T cell exhaustion.Frontiers in immunology · 2024Article
- A multiple-oscillator mechanism underlies antigen-induced CaThe Journal of biological chemistry · 2023Article
- Convergence of Calcium Channel Regulation and Mechanotransduction in Skeletal Regenerative Biomaterial Design.Advanced healthcare materials · 2023Review
- CaCellular signalling · 2023Review
- Neuronal Store-Operated Calcium Channels.Molecular neurobiology · 2023Review
- Molecular targeted therapy: A new avenue in glioblastoma treatment.Oncology letters · 2023Review
- STIM1 and ORAI1 form a novel cold transduction mechanism in sensory and sympathetic neurons.The EMBO journal · 2023Article
- Mechanisms underlying divergent relationships between CaThe Journal of physiology · 2023Article
- S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.International journal of biological sciences · 2023Article
- Piezo1 activation facilitates ovarian cancer metastasis via Hippo/YAP signaling axis.Channels (Austin, Tex.) · 2022Article
- Structure and function of the N-terminal extension of the formin INF2.Cellular and molecular life sciences : CMLS · 2022Article
- Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma.Cells · 2022Review
- Calmodulin activates the Hippo signaling pathway by promoting LATS1 kinase-mediated inhibitory phosphorylation of the transcriptional coactivator YAP.The Journal of biological chemistry · 2022Article
- Dual effect of nifedipine on pregnant human myometrium contractility: Implication of TRPC1.Journal of cellular physiology · 2022Article
- Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma.Frontiers in molecular neuroscience · 2022Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Zhijun LiuDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Yiju WeiDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Lei ZhangDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Patricia P YeeDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Martin JohnsonDepartment of Cellular & Molecular Physiology, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Xuexin ZhangDepartment of Cellular & Molecular Physiology, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Melissa GulleyDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Jennifer M AtkinsonDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Mohamed TrebakDepartment of Cellular & Molecular Physiology, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Hong-Gang WangDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Wei LiDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA. weili@pennstatehealth.psu.edu.ORCID http://orcid.org/0000-0001-5696-4309
Penn State Milton S. Hershey Medical Center · USTongji Hospital · CN
Funding
Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7MReceptor-regulated Ca2+ Entry Pathways in Smooth MuscleR01HL097111 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2010 to 2019
$3.7MNRSA Training CoreTL1TR002016 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI THOMAS, GAIL D. · 2016 to 2025
$3.4MMedical Student Training ProgramT32GM118294 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LEVENSON, ROBERT · 2016 to 2021
$1.7MLeukotriene C4 and STIM/Orai channels in airway smooth muscle remodelingR01HL123364 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2014 to 2017
$1.5MThe mechanism and function of cell competition in tumorsK22CA190440 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LI, WEI · 2015 to 2017
$526kGenes and miRNAs controlled by ORAI3 in cardiovascular remodelingR21AG050072 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEBECHE, DJAMEL, TREBAK, MOHAMED · 2016 to 2017
$471kAmerican Association for Cancer Research (AACR) 14-20-10-LINCATS NIH HHS TL1 TR002016NCATS NIH HHS UL1 TR002014NCI NIH HHS K22 CA190440NHLBI NIH HHS R01 HL097111NHLBI NIH HHS R01 HL123364NIA NIH HHS R21 AG050072NIGMS NIH HHS T32 GM118294U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5K22CA190440U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5T32GM118294
Abstract
Glioblastomas (GBM) are the most aggressive brain cancers without effective therapeutics. The Hippo pathway transcriptional coactivators YAP/TAZ were implicated as drivers in GBM progression and could be therapeutic targets. Here we found in an unbiased screen of 1650 compounds that amlodipine is able to inhibit survival of GBM cells by suppressing YAP/TAZ activities. Instead of its known function as an L-type calcium channel blocker, we found that amlodipine is able to activate Ca
Indexed as
AcyltransferasesAdaptor Proteins, Signal TransducingAmlodipineAnimalsCalciumCalcium Channel BlockersCalcium SignalingCell Line, TumorEndoplasmic ReticulumEnzyme ActivationFemaleGene Knockdown TechniquesGlioblastomaHippo Signaling PathwayHumansIonomycinAcyltransferasesAdaptor Proteins, Signal TransducingAmlodipineCalciumCalcium Channel BlockersIonomycinNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanPhosphoproteinsProtein Kinase C betaProtein KinasesProtein Serine-Threonine KinasesRecombinant ProteinsRNA, Small InterferingTAFAZZIN protein, humanThapsigarginTranscription FactorsYAP1 protein, humanYAP-Signaling Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.